Diphenoxylate has 1 known drug interaction based on U.S. FDA drug labeling data. Notable interactions include combinations with Digoxin. Patients taking Diphenoxylate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 1
- Moderate
- 1
Moderate (1)
- Diphenoxylate + Digoxin— Increases digoxin concentrations; magnitude unclear. Requires monitoring and dose adjustment.