Buprenorphine And Naloxone has 15 known drug interactions based on U.S. FDA drug labeling data. 12 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alcohol, Erythromycin, Gabapentin. Patients taking Buprenorphine And Naloxone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 15
- Major
- 12
- Moderate
- 1
Major (12)
- Buprenorphine And Naloxone + Alcohol— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
- Buprenorphine And Naloxone + Erythromycin— CYP3A4 inhibitor that increases buprenorphine plasma concentration, resulting in increased or prolonged opioid effects.
- Buprenorphine And Naloxone + Gabapentin— CNS depressant that increases risk of respiratory depression, profound sedation, coma, and death when used concomitantly…
- Buprenorphine And Naloxone + Ketoconazole— CYP3A4 inhibitor (azole-antifungal) that increases buprenorphine plasma concentration, resulting in increased or prolong…
- Buprenorphine And Naloxone + Muscle Relaxants— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
- Buprenorphine And Naloxone + Nitrazepam— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
- Buprenorphine And Naloxone + Pregabalin— CNS depressant that increases risk of respiratory depression, profound sedation, coma, and death when used concomitantly…
- Buprenorphine And Naloxone + Ritonavir— CYP3A4 inhibitor (protease inhibitor) that increases buprenorphine plasma concentration, resulting in increased or prolo…
- Buprenorphine And Naloxone + Sedating Antihistamines— CNS depressant effects increase risk of respiratory depression, profound sedation, coma, and death.
- Buprenorphine And Naloxone + Sedatives— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
- Buprenorphine And Naloxone + Topical Local Anesthetics— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
- Buprenorphine And Naloxone + Tranquilizers— CNS depressant effects increase risk of respiratory depression, profound sedation, coma, and death.
Moderate (1)
- Buprenorphine And Naloxone + Atazanavir— Other PIs with CYP3A4 inhibitory activity (atazanavir and atazanavir/ritonavir) resulted in elevated levels of buprenorp…