Escitalopram Oxalate has 24 known drug interactions based on U.S. FDA drug labeling data. Of these, 6 are contraindicated combinations that should be avoided entirely. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Linezolid, Maois, Methylene Blue. Patients taking Escitalopram Oxalate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 24
- Contraindicated
- 6
- Major
- 7
- Moderate
- 6
- Minor
- 1
Contraindicated (6)
- Escitalopram Oxalate + Linezolid— Concomitant use increases risk of serotonin syndrome. Escitalopram oxalate is contraindicated in patients taking linezol…
- Escitalopram Oxalate + Maois— Concomitant use with MAOIs is contraindicated due to risk of serotonin syndrome.
- Escitalopram Oxalate + Methylene Blue— Concomitant use increases risk of serotonin syndrome. Escitalopram oxalate is contraindicated in patients taking intrave…
- Escitalopram Oxalate + Monoamine Oxidase Inhibitors (Maois)— Concomitant use with MAOIs is contraindicated due to risk of serious adverse reactions including serotonin syndrome.
- Escitalopram Oxalate + Pimozide— Concomitant use increases plasma concentrations of pimozide and may increase risk of QT prolongation and ventricular arr…
- Escitalopram Oxalate + Tryptophan— Concomitant use with tryptophan is not recommended due to risk of serotonin syndrome.
Major (7)
- Escitalopram Oxalate + Amphetamine— Serotonergic drug that increases risk of serotonin syndrome when combined with escitalopram oxalate.
- Escitalopram Oxalate + Buspirone— Serotonergic drug that increases risk of serotonin syndrome when combined with escitalopram oxalate.
- Escitalopram Oxalate + Lithium— Serotonergic drug that increases risk of serotonin syndrome when combined with escitalopram oxalate.
- Escitalopram Oxalate + St. John'S Wort— Serotonergic agent that increases risk of serotonin syndrome when combined with escitalopram oxalate.
- Escitalopram Oxalate + Sumatriptan— Postmarketing reports describe weakness, hyperreflexia, and incoordination following concomitant use. Appropriate patien…
- Escitalopram Oxalate + Triptans— Rare postmarketing reports of serotonin syndrome with SSRIs and triptans. Careful observation advised during treatment i…
- Escitalopram Oxalate + Warfarin— Concomitant use may potentiate the risk of bleeding. Carefully monitor international normalized ratio in patients taking…
Moderate (6)
- Escitalopram Oxalate + Acetylsalicylic Acid— Concomitant use may potentiate risk of bleeding. Patients should be informed of increased bleeding risk.
- Escitalopram Oxalate + Alcohol— Use is not recommended with escitalopram despite lack of potentiation in clinical trials, consistent with other psychotr…
- Escitalopram Oxalate + Carbamazepine— Carbamazepine may increase clearance of escitalopram due to its enzyme-inducing properties. Consider possibility of incr…
- Escitalopram Oxalate + Cimetidine— Increases citalopram AUC by 43% and Cmax by 39%; clinical significance unknown.
- Escitalopram Oxalate + Cns Drugs— Caution should be used when escitalopram is combined with other centrally acting drugs.
- Escitalopram Oxalate + Nsaids— Use with caution; concurrent use may potentiate the risk of upper gastrointestinal bleeding.
Minor (1)
- Escitalopram Oxalate + Digoxin— Combined administration did not significantly affect pharmacokinetics of either citalopram or digoxin in clinical studie…