Risperidone has 33 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Methylphenidate Hydrochloride, Tetrabenazine, Alcohol. Patients taking Risperidone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 33
- Major
- 2
- Moderate
- 27
- Minor
- 4
Major (2)
- Risperidone + Methylphenidate Hydrochloride— Combined use with dosage changes in either medication may increase risk of extrapyramidal symptoms; monitor for signs of…
- Risperidone + Tetrabenazine— Antipsychotic that increases risk for Parkinsonism, NMS, and akathisia when used concomitantly with tetrabenazine.
Moderate (27)
- Risperidone + Alcohol— Caution should be used due to additive CNS effects when alcohol is administered with risperidone.
- Risperidone + Bupropion— CYP2D6 substrate; bupropion inhibits CYP2D6 and increases risperidone concentrations; consider dose reduction.
- Risperidone + Bupropion Hcl Er— Bupropion inhibits CYP2D6 and can increase risperidone concentrations; consider dose reduction of risperidone.
- Risperidone + Bupropion Hcl Er (Xl)— CYP2D6 substrate antipsychotic. Bupropion inhibits CYP2D6, increasing risperidone exposure. Dose reduction may be necess…
- Risperidone + Bupropion Hydrobromide— CYP2D6 substrate antipsychotic. Bupropion inhibits CYP2D6 and can increase risperidone concentrations. Consider dose red…
- Risperidone + Bupropion Hydrochloride— CYP2D6-metabolized antipsychotic. Bupropion inhibits CYP2D6 and can increase risperidone concentrations. Consider dose r…
- Risperidone + Carbamazepine— Enzyme inducer that decreases plasma concentrations of risperidone. Increase risperidone dose up to double the patient's…
- Risperidone + Carbidopa— Dopamine D2 receptor antagonists may reduce the therapeutic effects of levodopa; patients should be carefully observed f…
- Risperidone + Carbidopa And Levodopa— Dopamine D2 receptor antagonists may reduce the therapeutic effects of levodopa; patients should be carefully observed f…
- Risperidone + Carbidopa Tablets— Dopamine D2 receptor antagonist may reduce therapeutic effects of levodopa; patients should be carefully observed for lo…
- Risperidone + Carbidopa, Levodopa And Entacapone— Dopamine D2 receptor antagonist may reduce therapeutic effects of levodopa.
- Risperidone + Cimetidine— Cimetidine increases the bioavailability of risperidone by 64%, though it does not affect combined AUC of risperidone an…
- Risperidone + Clozapine— Chronic administration of clozapine may decrease the clearance of risperidone.
- Risperidone + Dexmethylphenidate Hydrochloride— Combined use with dosage changes in either or both medications may increase risk of extrapyramidal symptoms. Monitor for…
- Risperidone + Dopamine Agonists— Risperidone may antagonize the effects of dopamine agonists.
- Risperidone + Erythromycin— 7.2 Drugs Having No Clinically Important Interactions with PERSERIS Based on pharmacokinetic studies with oral risperido…
- Risperidone + Fluoxetine— CYP2D6 enzyme inhibitor increases plasma concentrations of risperidone. Reduce initial dose and do not exceed 8 mg per d…
- Risperidone + Foscarbidopa/Foslevodopa— Dopamine D2 receptor antagonist may reduce effectiveness of foslevodopa. Monitor for worsening Parkinson's symptoms.
- Risperidone + Levodopa— Risperidone may antagonize the effects of levodopa.
- Risperidone + Methylphenidate— Concomitant use with methylphenidate may increase the risk of extrapyramidal symptoms (EPS), especially with dosage chan…
- Risperidone + Methylphenidate Hydrochloride Extended Release— Combined use with dosage changes may increase risk of extrapyramidal symptoms. Monitor for signs of EPS.
- Risperidone + Naltrexone Hydrochloride And Bupropion Hydrochloride— Bupropion inhibits CYP2D6 and can increase risperidone concentrations. Consider dose reduction when using with CONTRAVE.
- Risperidone + Paroxetine— CYP2D6 enzyme inhibitor increases plasma concentrations of risperidone. Reduce initial dose and do not exceed 8 mg per d…
- Risperidone + Paroxetine Hydrochloride— Increased exposure of CYP2D6 substrate; decrease dosage if needed.
- Risperidone + Paroxetine Hydrochloride Hemihydrate— Paroxetine inhibits CYP2D6 metabolism of risperidone, potentially increasing risperidone levels.
- Risperidone + Ranitidine— Ranitidine increases the bioavailability of risperidone by 26% and increases combined AUC of risperidone and 9-hydroxyri…
- Risperidone + Serdexmethylphenidate And Dexmethylphenidate— Combined use with methylphenidate, especially with dosage changes, may increase the risk of extrapyramidal symptoms (EPS…
Minor (4)
- Risperidone + Amitriptyline— Minor effect on risperidone exposure. Dose adjustment not needed.
- Risperidone + Digoxin— Risperidone does not show clinically relevant effect on digoxin pharmacokinetics. Dose adjustment for digoxin not recomm…
- Risperidone + Lithium— Risperidone does not affect lithium exposure. Dose adjustment for lithium not recommended.
- Risperidone + Valproate— Risperidone increases valproate peak plasma concentration by 20%. Dose adjustment for valproate not recommended.