Bortezomib has 7 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cyp3a Inducers, Mao Inhibitors, Thalidomide. Patients taking Bortezomib should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 7
- Major
- 2
- Moderate
- 1
- Minor
- 4
Major (2)
- Bortezomib + Cyp3a Inducers— Coadministration decreases bortezomib exposure which may decrease efficacy. Avoid concomitant use.
- Bortezomib + Mao Inhibitors— Coadministration increases bortezomib exposure and may increase risk of bortezomib toxicities. Monitor for toxicity and …
Moderate (1)
- Bortezomib + Thalidomide— Bortezomib causes peripheral neuropathy and concomitant use with thalidomide can cause additive effect; should be used w…
Minor (4)
- Bortezomib + Dexamethasone— No clinically significant drug interactions observed when coadministered with bortezomib.
- Bortezomib + Melphalan— No clinically significant drug interactions observed when coadministered with bortezomib in combination with prednisone.
- Bortezomib + Omeprazole— No clinically significant drug interactions observed when coadministered with bortezomib.
- Bortezomib + Prednisone— No clinically significant drug interactions observed when melphalan coadministered with bortezomib in combination with p…