Salsalate has 15 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Aspirin, Lithium, Methotrexate. Patients taking Salsalate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 15
- Contraindicated
- 1
- Major
- 4
- Moderate
- 10
Contraindicated (1)
- Salsalate + Aspirin— Aspirin and other salicylate drugs are additive to salsalate and may increase plasma concentrations of salicylic acid to…
Major (4)
- Salsalate + Lithium— NSAIDs may elevate plasma lithium levels and reduce renal lithium clearance, increasing lithium toxicity risk. Subjects …
- Salsalate + Methotrexate— NSAIDs may competitively inhibit methotrexate accumulation and enhance methotrexate toxicity. Caution should be used whe…
- Salsalate + Oral Anticoagulants— Salicylates given concomitantly with anticoagulant drugs may predispose to systemic bleeding.
- Salsalate + Warfarin— The effects of warfarin and NSAIDs on GI bleeding are synergistic, resulting in a higher risk of serious GI bleeding tha…
Moderate (10)
- Salsalate + Furosemide— Salsalate can reduce the natriuretic effect of furosemide in some patients. Patient should be observed for signs of rena…
- Salsalate + Levothyroxine— Salicylate competes with thyroxine for protein binding sites, potentially affecting drug levels.
- Salsalate + Naproxen— Salicylate competes with naproxen for protein binding sites, potentially affecting drug levels.
- Salsalate + Penicillin— Salicylate competes with penicillin for protein binding sites, potentially affecting drug levels.
- Salsalate + Phenytoin— Salicylate competes with phenytoin for protein binding sites, potentially affecting drug levels.
- Salsalate + Sulfinpyrazone— Salicylate competes with sulfinpyrazone for protein binding sites, potentially affecting drug levels.
- Salsalate + Sulfonylurea— Salicylates may enhance the hypoglycemic effect of oral antidiabetic drugs of the sulfonylurea class.
- Salsalate + Thiazides— Salsalate can reduce the natriuretic effect of thiazides in some patients. Close observation for renal failure and diure…
- Salsalate + Thiopental— Salicylate competes with thiopental for protein binding sites, potentially affecting drug levels.
- Salsalate + Triiodothyronine— Salicylate competes with triiodothyronine for protein binding sites, potentially affecting drug levels.