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Dobutamine

Also known as: Dobutamine

Route: Intravenous

12 interactions on record

Dobutamine has 12 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Sodium Bicarbonate, Sodium Bicarbonate Injection,, Adrenergic Blockers. Patients taking Dobutamine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 12
Contraindicated: 2
Major: 3
Moderate: 6

Contraindicated (2)

Dobutamine + Sodium Bicarbonate— Incompatible with sodium bicarbonate solution; do not combine.
Dobutamine + Sodium Bicarbonate Injection,— Dobutamine is incompatible with sodium bicarbonate solution and should not be admixed.

Major (3)

Dobutamine + Adrenergic Blockers— Dobutamine may be ineffective if recently preceded by β-blockers; peripheral vascular resistance may increase.
Dobutamine + Carbidopa, Levodopa And Entacapone— May result in increased heart rates, possibly arrhythmias, and excessive changes in blood pressure. Metabolized by COMT.
Dobutamine + ß-Blocking Drugs— Dobutamine may be ineffective if patient has recently received a ß-blocking drug, with potential increase in peripheral …

Moderate (6)

Dobutamine + Atomoxetine— Pressor agent that may cause effects on blood pressure when used with atomoxetine; use with caution.
Dobutamine + Atomoxetine Hydrochloride— Pressor agent; possible effects on blood pressure when used with atomoxetine.
Dobutamine + Entacapone— Concomitant use of dobutamine and COMT inhibitors may result in increased heart rate, arrhythmias, and changes in blood …
Dobutamine + Nitroprusside— Concomitant use results in higher cardiac output and usually lower pulmonary wedge pressure compared to either drug alon…
Dobutamine + Propranolol Hydrochloride— Propranolol may reduce sensitivity to dobutamine stress echocardiography in patients undergoing myocardial ischemia eval…
Dobutamine + Tolcapone— Tolcapone may influence pharmacokinetics of COMT substrates like dobutamine. Dose reduction should be considered when co…

Dobutamine + Sodium Bicarbonate⛔Contraindicated

Incompatible with sodium bicarbonate solution; do not combine.

Dobutamine + Sodium Bicarbonate Injection,⛔Contraindicated

Dobutamine is incompatible with sodium bicarbonate solution and should not be admixed.

Dobutamine + Adrenergic Blockers⚠️Major

Dobutamine may be ineffective if recently preceded by β-blockers; peripheral vascular resistance may increase.

Dobutamine + Carbidopa, Levodopa And Entacapone⚠️Major

May result in increased heart rates, possibly arrhythmias, and excessive changes in blood pressure. Metabolized by COMT.

Dobutamine + ß-Blocking Drugs⚠️Major

Dobutamine may be ineffective if patient has recently received a ß-blocking drug, with potential increase in peripheral vascular resistance.

Dobutamine + Atomoxetine🟡Moderate

Pressor agent that may cause effects on blood pressure when used with atomoxetine; use with caution.

Dobutamine + Atomoxetine Hydrochloride🟡Moderate

Pressor agent; possible effects on blood pressure when used with atomoxetine.

Dobutamine + Entacapone🟡Moderate

Concomitant use of dobutamine and COMT inhibitors may result in increased heart rate, arrhythmias, and changes in blood pressure.

Dobutamine + Nitroprusside🟡Moderate

Concomitant use results in higher cardiac output and usually lower pulmonary wedge pressure compared to either drug alone.

Dobutamine + Propranolol Hydrochloride🟡Moderate

Propranolol may reduce sensitivity to dobutamine stress echocardiography in patients undergoing myocardial ischemia evaluation.

Dobutamine + Tolcapone🟡Moderate

Tolcapone may influence pharmacokinetics of COMT substrates like dobutamine. Dose reduction should be considered when co-administered.

Dobutamine + Furosemideℹ️Unknown

There was no evidence of drug interactions in clinical studies in which dobutamine was administered concurrently with other drugs, including digitalis preparations, furosemide, spironolactone, lidocaine, glyceryl trinitrate, isosorbide dinitrate, morphine, atropine, heparin, protamine, potassium chloride, folic acid, and acetaminophen.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.