Sevoflurane has 22 known drug interactions based on U.S. FDA drug labeling data. 13 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Calcium Antagonists, Dexmedetomidine, Dexmedetomidine Hydrochloride. Patients taking Sevoflurane should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 22
- Major
- 13
- Moderate
- 8
- Minor
- 1
Major (13)
- Sevoflurane + Calcium Antagonists— Sevoflurane may lead to marked hypotension in patients treated with calcium antagonists. Blood pressure should be closel…
- Sevoflurane + Dexmedetomidine— Concomitant use may cause enhanced CNS depressant effects. Dosage reduction of dexmedetomidine or sevoflurane may be req…
- Sevoflurane + Dexmedetomidine Hydrochloride— Enhancement of pharmacodynamic effects. Reduction in dosage of dexmedetomidine or sevoflurane may be required.
- Sevoflurane + Dexmethylphenidate Hydrochloride— Concomitant use may increase risk of sudden blood pressure and heart rate increase during surgery. Avoid use on day of s…
- Sevoflurane + Dopamine Hydrochloride— Concomitant use may increase cardiac autonomic irritability and sensitize the myocardium to dopamine, potentially leadin…
- Sevoflurane + Epinephrine— Epinephrine administered with sevoflurane may increase the risk of ventricular arrhythmias. Monitor electrocardiogram an…
- Sevoflurane + Mao Inhibitors— Concomitant use of MAO inhibitors and sevoflurane may increase the risk of hemodynamic instability during surgery or med…
- Sevoflurane + Methylphenidate Hydrochloride— Concomitant use may increase risk of sudden blood pressure and heart rate increase during surgery. Avoid use on day of s…
- Sevoflurane + Methylphenidate Hydrochloride Extended Release— Concomitant use may increase risk of sudden blood pressure and heart rate increase during surgery. Avoid on day of surge…
- Sevoflurane + Norepinephrine Bitartrate— Concomitant use may lead to ventricular tachycardia or ventricular fibrillation. Monitor cardiac rhythm.
- Sevoflurane + Propofol— Increases anesthetic/sedative and cardiorespiratory effects of propofol during maintenance anesthesia. Concurrent use is…
- Sevoflurane + Succinylcholine— Concomitant use associated with perioperative hyperkalemia risk.
- Sevoflurane + Verapamil— In animals, impairment of atrioventricular conduction has been observed when verapamil and sevoflurane are administered …
Moderate (8)
- Sevoflurane + Alfentanil— Sevoflurane potentiates neuromuscular block when used to supplement alfentanil-N2O anesthesia.
- Sevoflurane + Atracurium— Sevoflurane increases both the intensity and duration of neuromuscular blockade induced by atracurium. Dosage adjustment…
- Sevoflurane + Dexmedetomidine Hydrochloride In 0.9% Sodium Chloride— Co-administration leads to enhancement of pharmacodynamic effects. Reduction in dosage of dexmedetomidine or sevoflurane…
- Sevoflurane + Nitrazepam— Benzodiazepines decrease the MAC of sevoflurane; sevoflurane is compatible with benzodiazepines as commonly used in surg…
- Sevoflurane + Nitrous Oxide— Anesthetic requirement for sevoflurane is decreased when administered in combination with nitrous oxide; MAC equivalent …
- Sevoflurane + Pancuronium— Sevoflurane increases both the intensity and duration of neuromuscular blockade induced by pancuronium. Dosage adjustmen…
- Sevoflurane + Propofol Injectable Emulsion— Concurrent administration during maintenance can increase anesthetic/sedative and cardiorespiratory effects of propofol.
- Sevoflurane + Vecuronium— Sevoflurane increases both the intensity and duration of neuromuscular blockade induced by vecuronium. Dosage adjustment…
Minor (1)
- Sevoflurane + Barbiturates— Sevoflurane administration is compatible with barbiturates and other commonly used intravenous anesthetics.