Sodium Bicarbonate has 20 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate, Dobutamine, Norepinephrine. Patients taking Sodium Bicarbonate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 20
- Contraindicated
- 3
- Major
- 4
- Moderate
- 13
Contraindicated (3)
- Sodium Bicarbonate + Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate— Gastrointestinal alkalinizing agent that increases amphetamine blood levels and potentiates action. Co-administration sh…
- Sodium Bicarbonate + Dobutamine— Incompatible with sodium bicarbonate solution; do not combine.
- Sodium Bicarbonate + Norepinephrine— Incompatible with sodium bicarbonate solution; do not combine.
Major (4)
- Sodium Bicarbonate + Acetazolamide— Concurrent use with acetazolamide increases the risk of renal calculus formation.
- Sodium Bicarbonate + Amphetamine Sulfate— Gastrointestinal alkalinizing agent that increases amphetamine absorption and blood levels, potentiating amphetamine act…
- Sodium Bicarbonate + Calcium Antagonists— Addition of sodium bicarbonate to parenteral solutions containing calcium should be avoided; precipitation or haze may r…
- Sodium Bicarbonate + Dextroamphetamine Sulfate— Gastrointestinal alkalinizing agent increases blood levels and potentiates amphetamine action. Concomitant use should be…
Moderate (13)
- Sodium Bicarbonate + Acetazolamide Extended-Release— Acetazolamide and sodium bicarbonate used concurrently increase the risk of renal calculus formation.
- Sodium Bicarbonate + Acetazolamide Sodium— Concurrent use with acetazolamide increases the risk of renal calculus formation.
- Sodium Bicarbonate + Amantadine— Alters urine pH toward alkaline conditions, potentially leading to amantadine accumulation and increased adverse reactio…
- Sodium Bicarbonate + Amphetamine— Gastrointestinal alkalinizing agent that increases amphetamine absorption and blood levels, potentiating effects.
- Sodium Bicarbonate + Cefpodoxime Proxetil— High doses reduce peak plasma levels by 24-42% and extent of absorption by 27-32%, but do not alter absorption rate.
- Sodium Bicarbonate + Dextroamphetamine— Gastrointestinal alkalinizing agent increases amphetamine absorption, raising blood levels and potentiating actions.
- Sodium Bicarbonate + Lithium Carbonate— Lowers serum lithium concentrations by increasing urinary lithium excretion; monitor lithium levels.
- Sodium Bicarbonate + Memantine— Sodium bicarbonate alters urine pH towards alkaline conditions, reducing memantine clearance by about 80% and potentiall…
- Sodium Bicarbonate + Memantine Hydrochloride— Sodium bicarbonate alters urine pH towards alkaline conditions, which may reduce memantine clearance by about 80% and le…
- Sodium Bicarbonate + Memantine Hydrochloride And Donepezil Hydrochloride— Sodium bicarbonate may alter urine pH towards alkaline conditions, reducing memantine clearance by about 80% and leading…
- Sodium Bicarbonate + Quinidine Gluconate— Sodium bicarbonate alkalinizes urine and reduces renal elimination of quinidine.
- Sodium Bicarbonate + Quinidine Sulfate Tablet— Alkalinizes urine and reduces renal elimination of quinidine, increasing quinidine levels.
- Sodium Bicarbonate + Tetracycline Hydrochloride— Sodium bicarbonate impairs absorption of tetracycline.