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Acetazolamide Extended-Release

Also known as: Acetazolamide Extended-Release

Carbonic Anhydrase InhibitorCarbonic Anhydrase Inhibitors

Route: Oral

Check Acetazolamide Extended-Release Interactions →

12 interactions on record

Acetazolamide Extended-Release has 12 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Acetazolamide, Amphetamine, Cyclosporine. Patients taking Acetazolamide Extended-Release should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 12
Moderate: 11

Moderate (11)

Acetazolamide Extended-Release + Acetazolamide— Drug Interactions Aspirin - See WARNINGS Acetazolamide modifies phenytoin metabolism with increased serum levels of phen…
Acetazolamide Extended-Release + Amphetamine— Acetazolamide decreases urinary excretion of amphetamine and may enhance the magnitude and duration of its effect.
Acetazolamide Extended-Release + Cyclosporine— Acetazolamide may elevate cyclosporine levels.
Acetazolamide Extended-Release + Folic Acid— Acetazolamide may increase the effects of other folic acid antagonists.
Acetazolamide Extended-Release + Lithium— Acetazolamide increases lithium excretion, which may lead to decreased lithium levels.
Acetazolamide Extended-Release + Mao Inhibitors— Concomitant use with other carbonic anhydrase inhibitors is not advisable due to possible additive effects.
Acetazolamide Extended-Release + Methenamine Salts— Acetazolamide may prevent the urinary antiseptic effect of methenamine.
Acetazolamide Extended-Release + Phenytoin— Acetazolamide modifies phenytoin metabolism with increased serum levels, which may increase or enhance osteomalacia occu…
Acetazolamide Extended-Release + Primidone— Acetazolamide decreases gastrointestinal absorption of primidone, reducing serum concentrations and possibly decreasing …
Acetazolamide Extended-Release + Quinidine— Acetazolamide reduces urinary excretion of quinidine and may enhance its effect.
Acetazolamide Extended-Release + Sodium Bicarbonate— Acetazolamide and sodium bicarbonate used concurrently increase the risk of renal calculus formation.

Acetazolamide Extended-Release + Acetazolamide🟡Moderate

Drug Interactions Aspirin - See WARNINGS Acetazolamide modifies phenytoin metabolism with increased serum levels of phenytoin. By decreasing the gastrointestinal absorption of primidone, acetazolamide may decrease serum concentrations of primidone and its metabolites, with a consequent possible decrease in anticonvulsant effect. Caution is advised when beginning, discontinuing, or changing the dose of acetazolamide in patients receiving primidone.

Acetazolamide Extended-Release + Amphetamine🟡Moderate

Acetazolamide decreases urinary excretion of amphetamine and may enhance the magnitude and duration of its effect.

Acetazolamide Extended-Release + Cyclosporine🟡Moderate

Acetazolamide may elevate cyclosporine levels.

Acetazolamide Extended-Release + Folic Acid🟡Moderate

Acetazolamide may increase the effects of other folic acid antagonists.

Acetazolamide Extended-Release + Lithium🟡Moderate

Acetazolamide increases lithium excretion, which may lead to decreased lithium levels.

Acetazolamide Extended-Release + Mao Inhibitors🟡Moderate

Concomitant use with other carbonic anhydrase inhibitors is not advisable due to possible additive effects.

Acetazolamide Extended-Release + Methenamine Salts🟡Moderate

Acetazolamide may prevent the urinary antiseptic effect of methenamine.

Acetazolamide Extended-Release + Phenytoin🟡Moderate

Acetazolamide modifies phenytoin metabolism with increased serum levels, which may increase or enhance osteomalacia occurrence in patients on chronic phenytoin therapy.

Acetazolamide Extended-Release + Primidone🟡Moderate

Acetazolamide decreases gastrointestinal absorption of primidone, reducing serum concentrations and possibly decreasing anticonvulsant effect. Caution advised when beginning, discontinuing, or changing acetazolamide dose.

Acetazolamide Extended-Release + Quinidine🟡Moderate

Acetazolamide reduces urinary excretion of quinidine and may enhance its effect.

Acetazolamide Extended-Release + Sodium Bicarbonate🟡Moderate

Acetazolamide and sodium bicarbonate used concurrently increase the risk of renal calculus formation.

Acetazolamide Extended-Release + Acetylsalicylic Acidℹ️Unknown

Interaction noted in WARNINGS section; specific details refer to warnings for severity information.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.