Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets has 43 known drug interactions based on U.S. FDA drug labeling data. Of these, 4 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Dasabuvir, Ombitasvir, Paritaprevir. Patients taking Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 43
- Contraindicated
- 4
- Moderate
- 33
- Minor
- 2
Contraindicated (4)
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Dasabuvir— 7.3 Concomitant Use with Hepatitis C Virus (HCV) Combination Therapy – Liver Enzyme Elevation Co-administration of levon…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Ombitasvir— 7.3 Concomitant Use with Hepatitis C Virus (HCV) Combination Therapy – Liver Enzyme Elevation Co-administration of levon…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Paritaprevir— 7.3 Concomitant Use with Hepatitis C Virus (HCV) Combination Therapy – Liver Enzyme Elevation Co-administration of levon…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Ritonavir— Human immunodeficiency virus (HIV)/hepatitis C virus (HCV) protease inhibitors and non-nucleoside reverse transcriptase …
Moderate (33)
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Amprenavir— Amprenavir/ritonavir, an HIV protease inhibitor, may significantly decrease plasma concentrations of estrogen and/or pro…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Aprepitant— Aprepitant induces CYP3A4 and may decrease plasma concentrations of COCs, potentially diminishing contraceptive effectiv…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Atazanavir— Atazanavir/ritonavir, an HIV protease inhibitor, may significantly increase plasma concentrations of estrogen and/or pro…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Atorvastatin— Atorvastatin increases AUC of ethinyl estradiol by approximately 20 to 25% when co-administered with certain COCs.
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Barbiturates— Barbiturates induce CYP3A4 and may decrease plasma concentrations of COCs, potentially diminishing contraceptive effecti…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Boceprevir— Boceprevir, an HCV protease inhibitor, may significantly decrease plasma concentrations of estrogen and/or progestin.
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Bosentan— Bosentan induces CYP3A4 and may decrease plasma concentrations of COCs, potentially diminishing contraceptive effectiven…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Carbamazepine— Carbamazepine induces CYP3A4 and may decrease plasma concentrations of COCs, potentially diminishing contraceptive effec…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Colesevelam— Colesevelam significantly decreases the AUC of ethinyl estradiol. Taking colesevelam 4 hours apart from the COC may decr…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Darunavir— Darunavir/ritonavir, an HIV protease inhibitor, may significantly decrease plasma concentrations of estrogen and/or prog…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Efavirenz— Efavirenz, a non-nucleoside reverse transcriptase inhibitor, may significantly decrease plasma concentrations of estroge…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Etravirine— Etravirine, a non-nucleoside reverse transcriptase inhibitor, may significantly increase plasma concentrations of estrog…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Felbamate— Felbamate induces CYP3A4 and may decrease plasma concentrations of COCs, potentially diminishing contraceptive effective…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Fluconazole— Fluconazole, a CYP3A4 inhibitor, may increase plasma hormone concentrations of COCs.
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Grapefruit Juice— Grapefruit juice, a CYP3A4 inhibitor, may increase plasma hormone concentrations of COCs.
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Griseofulvin— Griseofulvin induces CYP3A4 and may decrease plasma concentrations of COCs, potentially diminishing contraceptive effect…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Indinavir— Indinavir, an HIV protease inhibitor, may significantly increase plasma concentrations of estrogen and/or progestin.
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Itraconazole— Itraconazole, a CYP3A4 inhibitor, may increase plasma hormone concentrations of COCs.
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Ketoconazole— Ketoconazole, a CYP3A4 inhibitor, may increase plasma hormone concentrations of COCs.
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Lopinavir— Lopinavir/ritonavir, an HIV protease inhibitor, may significantly decrease plasma concentrations of estrogen and/or prog…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Nelfinavir— Nelfinavir, an HIV protease inhibitor, may significantly decrease plasma concentrations of estrogen and/or progestin.
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Nevirapine— Nevirapine, a non-nucleoside reverse transcriptase inhibitor, may significantly decrease plasma concentrations of estrog…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Oxcarbazepine— Oxcarbazepine induces CYP3A4 and may decrease plasma concentrations of COCs, potentially diminishing contraceptive effec…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Phenytoin— Phenytoin induces CYP3A4 and may decrease plasma concentrations of COCs, potentially diminishing contraceptive effective…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Rifabutin— Rifabutin induces CYP3A4 and may decrease plasma concentrations of COCs, potentially diminishing contraceptive effective…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Rifampin— Rifampicin induces CYP3A4 and may decrease plasma concentrations of COCs, potentially diminishing contraceptive effectiv…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Rosuvastatin— Rosuvastatin increases AUC of ethinyl estradiol by approximately 20 to 25% when co-administered with certain COCs.
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Rufinamide— Rufinamide induces CYP3A4 and may decrease plasma concentrations of COCs, potentially diminishing contraceptive effectiv…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + St. John'S Wort— St. John's wort induces CYP3A4 and may decrease plasma concentrations of COCs, potentially diminishing contraceptive eff…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Telaprevir— Telaprevir, an HCV protease inhibitor, may significantly decrease plasma concentrations of estrogen and/or progestin.
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Tipranavir— Tipranavir/ritonavir, an HIV protease inhibitor, may significantly decrease plasma concentrations of estrogen and/or pro…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Topiramate— Topiramate induces CYP3A4 and may decrease plasma concentrations of COCs, potentially diminishing contraceptive effectiv…
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Voriconazole— Voriconazole, a CYP3A4 inhibitor, may increase plasma hormone concentrations of COCs.
Minor (2)
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Acetaminophen— Acetaminophen may increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
- Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets + Ascorbic Acid— Ascorbic acid may increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.