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Trandolapril Tablets

Also known as: Trandolapril

Angiotensin Converting Enzyme InhibitorAngiotensin-converting Enzyme Inhibitors

Route: Oral

Check Trandolapril Tablets Interactions →

12 interactions on record⛔ Black Box Warning

Trandolapril Tablets has 12 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Aliskiren, Angiotensin Ii, Lithium. Patients taking Trandolapril Tablets should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 12
Contraindicated: 1
Major: 3
Moderate: 8

Contraindicated (1)

Trandolapril Tablets + Aliskiren— Do not co-administer aliskiren with trandolapril in patients with diabetes. Avoid use in patients with renal impairment …

Major (3)

Trandolapril Tablets + Angiotensin Ii— Dual blockade of RAS associated with increased risks of hypotension, hyperkalemia, and changes in renal function includi…
Trandolapril Tablets + Lithium— ACE inhibitors can increase serum lithium levels and cause symptoms of lithium toxicity. Risk increased if a diuretic is…
Trandolapril Tablets + Trandolapril— Closely monitor blood pressure, renal function and electrolytes in patients on trandolapril and other agents that affect…

Moderate (8)

Trandolapril Tablets + Acidifying Agents— Concomitant use may increase blood glucose lowering effect with greater risk of hypoglycemia.
Trandolapril Tablets + Amiloride— Potassium-sparing diuretic that increases risk of hyperkalemia when used with ACE inhibitors. Use with caution and monit…
Trandolapril Tablets + Diuretics— May cause excessive reduction of blood pressure after initiation of trandolapril therapy. Starting dose of trandolapril …
Trandolapril Tablets + Insulin Human— Concomitant use may increase blood glucose lowering effect with greater risk of hypoglycemia.
Trandolapril Tablets + Magnesium Sulfate Heptahydrate— Concomitant use with ACE inhibitors increases risk of hyperkalemia. Use with caution and appropriate monitoring of serum…
Trandolapril Tablets + Potassium Supplements— Concomitant use with ACE inhibitors increases risk of hyperkalemia. Use with caution and appropriate monitoring of serum…
Trandolapril Tablets + Spironolactone— Potassium-sparing diuretic that increases risk of hyperkalemia when used with ACE inhibitors. Use with caution and monit…
Trandolapril Tablets + Triamterene— Potassium-sparing diuretic that increases risk of hyperkalemia when used with ACE inhibitors. Use with caution and monit…

Trandolapril Tablets + Aliskiren⛔Contraindicated

Do not co-administer aliskiren with trandolapril in patients with diabetes. Avoid use in patients with renal impairment (GFR <60 ml/min) due to increased risks of hypotension, hyperkalemia, and acute renal failure.

Trandolapril Tablets + Angiotensin Ii⚠️Major

Dual blockade of RAS associated with increased risks of hypotension, hyperkalemia, and changes in renal function including acute renal failure compared to monotherapy.

Trandolapril Tablets + Lithium⚠️Major

ACE inhibitors can increase serum lithium levels and cause symptoms of lithium toxicity. Risk increased if a diuretic is also used. Coadminister with caution and monitor serum lithium levels frequently.

Trandolapril Tablets + Trandolapril⚠️Major

Closely monitor blood pressure, renal function and electrolytes in patients on trandolapril and other agents that affect the RAS. Avoid use of aliskiren with trandolapril in patients with renal impairment (GFR <60 ml/min). Concomitant Diuretic Therapy As with other ACE inhibitors, patients on diuretics, especially those on recently instituted diuretic therapy, may experience an excessive reduction of blood pressure after initiation of therapy with trandolapril.

Trandolapril Tablets + Acidifying Agents🟡Moderate

Concomitant use may increase blood glucose lowering effect with greater risk of hypoglycemia.

Trandolapril Tablets + Amiloride🟡Moderate

Potassium-sparing diuretic that increases risk of hyperkalemia when used with ACE inhibitors. Use with caution and monitor serum potassium.

Trandolapril Tablets + Diuretics🟡Moderate

May cause excessive reduction of blood pressure after initiation of trandolapril therapy. Starting dose of trandolapril should be reduced or diuretic discontinued.

Trandolapril Tablets + Insulin Human🟡Moderate

Concomitant use may increase blood glucose lowering effect with greater risk of hypoglycemia.

Trandolapril Tablets + Magnesium Sulfate Heptahydrate🟡Moderate

Concomitant use with ACE inhibitors increases risk of hyperkalemia. Use with caution and appropriate monitoring of serum potassium.

Trandolapril Tablets + Potassium Supplements🟡Moderate

Concomitant use with ACE inhibitors increases risk of hyperkalemia. Use with caution and appropriate monitoring of serum potassium.

Trandolapril Tablets + Spironolactone🟡Moderate

Potassium-sparing diuretic that increases risk of hyperkalemia when used with ACE inhibitors. Use with caution and monitor serum potassium.

Trandolapril Tablets + Triamterene🟡Moderate

Potassium-sparing diuretic that increases risk of hyperkalemia when used with ACE inhibitors. Use with caution and monitor serum potassium.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.