May potentiate amphotericin B-induced hypokalemia, predisposing to cardiac dysfunction. Avoid concomitant use unless necessary; monitor serum electrolytes and cardiac function.
Source: NLP:amphotericin b
Repository Corticotropin Interactions
Brand names: Acthar
Adrenocorticotropic Hormone
Route: Intramuscular, Subcutaneous
Contraindications
4 CONTRAINDICATIONS Acthar Gel is contraindicated: for intravenous administration. in infants under 2 years of age who have suspected congenital infections. with concomitant administration of live or live attenuated vaccines in patients receiving immunosuppressive doses of Acthar Gel. in patients with scleroderma, osteoporosis, systemic fungal infections, ocular herpes simplex, recent surgery, history of or the presence of a peptic ulcer, congestive heart failure, uncontrolled hypertension, primary adrenocortical insufficiency, adrenocortical hyperfunction, or sensitivity to proteins of porcine origin. Acthar Gel is contraindicated: for intravenous administration ( 4 ) in infants under 2 years of age who have suspected congenital infections ( 4 ) with concomitant administration of live or live attenuated vaccines in patients receiving immunosuppressive doses of Acthar Gel ( 4 ) in patients with scleroderma, osteoporosis, systemic fungal infections, ocular herpes simplex, recent surgery, history of or the presence of a peptic ulcer, congestive heart failure, uncontrolled hypertension, primary adrenocortical insufficiency, adrenocortical hyperfunction, or sensitivity to proteins of porcine origin ( 4 )
Pregnancy & Breastfeeding
8.1 Pregnancy Risk Summary Based on Acthar Gel's pharmacological effect of stimulating an endogenous steroid response [see Clinical Pharmacology ( 12.1) ] , Acthar Gel may cause fetal harm when administered to a pregnant woman. The published literature on systemic corticosteroid use during pregnancy, which may be relevant, suggests potential concerns. Intrauterine growth restriction, decreased birth weight, and preterm birth have been reported with maternal use of corticosteroids; however, the underlying maternal condition may also contribute to these risks. Hypoadrenalism has also been reported in infants after high-dose and/or long-term use of corticosteroids during pregnancy (see Clinical Considerations ) . The potential adverse developmental effects of Acthar Gel have not been adequately assessed in animals. The estimated background risk of major birth defects and miscarriage for the indicated population(s) is unknown. All pregnancies have a background risk of birth defects, loss, or other adverse outcomes. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively. Clinical Considerations Fetal-Neonatal Adverse Reactions Hypoadrenalism has been reported in infants born to mothers treated with systemic corticosteroids during pregnancy. Infants born to mothers treated with Acthar Gel should be carefully observed for signs of hypoadrenalism, such as poor feeding, irritability, weakness, and vomiting, and managed accordingly [see Warnings and Precautions (5.2) ] .
24 interactions on record
Intensified electrolyte depletion, particularly hypokalemia, may occur with concurrent use of ACTH and chlorothiazide.
Source: NLP:chlorothiazide
Intensified electrolyte depletion, particularly hypokalemia, may occur when ACTH is given with chlorothiazide sodium.
Source: NLP:chlorothiazide sodium
Intensified electrolyte depletion, particularly hypokalemia may occur.
Source: NLP:hydrochlorothiazide
Corticotropin causes sodium and fluid retention; concomitant use may increase risk of hypernatremia and volume overload.
Source: NLP:sodium chloride, sodium gluconate, sodium acetate, potassium chloride and magnesium chloride
Avoid concomitant use due to increased risk of hypernatremia and volume overload. If unavoidable, closely monitor serum electrolytes and fluid balance.
Source: NLP:dextrose monohydrate, sodium chloride, sodium lactate, potassium chloride, calcium chloride
Concurrent use with sodium phosphate may result in hypernatremia.
Source: NLP:dibasic sodium phosphate, monobasic potassium phosphate and monobasic sodium phosphate
Intensified electrolyte depletion, particularly hypokalemia, may occur when used concurrently with hydrochlorothiazide.
Source: NLP:amiloride hydrochloride and hydrochlorothiazide
Large doses of ACTH may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs render tissues partly resistant to hyaluronidase action.
Source: NLP:hyaluronidase
May increase risk of hypokalemia and increase salt and water retention.
Source: NLP:metolazone
Concomitant use of ACTH with hydrochlorothiazide may cause hypokalemia, which can sensitize the heart to toxic effects of digitalis.
Source: NLP:metoprolol tartrate and hydrochlorothiazide
Caution must be exercised in the administration of Sodium Chloride Injection to patients receiving corticotropin due to potential interaction.
Source: NLP:0.9% sodium chloride
May increase risk of hypernatremia and volume overload. Monitor serum electrolytes, fluid balance, and acid-base balance if use cannot be avoided.
Source: NLP:sodium chloride and potassium chloride
Repository Corticotropin + Potassium Phosphate, Monobasic And Sodium Phosphate, Monobasic, AnhydrousModerate
Concurrent use with sodium phosphate may result in hypernatremia.
Source: NLP:potassium phosphate, monobasic and sodium phosphate, monobasic, anhydrous
Caution must be exercised when administering 0.45% Sodium chloride injection to patients receiving corticotropin due to potential interaction.
Source: NLP:sodium chloride
Concomitant use may increase risk of hypernatremia and volume overload. Avoid use; if unavoidable, monitor serum electrolytes, fluid balance, and acid-base balance.
Source: NLP:sodium chloride, potassium chloride, and calcium chloride
Concomitant use may increase risk of hypernatremia and volume overload. Monitor serum electrolytes, fluid balance and acid-base balance.
Source: NLP:sodium lactate, potassium chloride, magnesium chloride, monobasic potassium phosphate, sodium chloride and dextrose monohydrate
Intensified electrolyte depletion, particularly hypokalemia, may occur.
Source: NLP:spironolactone
Intensified electrolyte depletion, particularly hypokalemia, may occur.
Source: NLP:spironolactone and hydrochlorothiazide
Concurrent use with testosterone may result in increased fluid retention. Use with caution, particularly in patients with cardiac, renal, or hepatic disease.
Source: NLP:testosterone
Enhanced tendency toward edema; use caution, especially in patients with hepatic or cardiac disease.
Source: NLP:testosterone enanthate
Concurrent use with testosterone may result in increased fluid retention. Use with caution, particularly in patients with cardiac, renal, or hepatic disease.
Source: NLP:testosterone gel, 1%
Increased risk of hypokalemia when used concomitantly with torsemide.
Source: NLP:torsemide
Concurrent use with hydrochlorothiazide may intensify electrolyte imbalance, particularly hypokalemia, though triamterene presence minimizes this effect.
Source: NLP:triamterene and hydrochlorothiazide