Does Repository Corticotropin Interact with Metoprolol Tartrate And Hydrochlorothiazide?
Repository Corticotropin and Metoprolol Tartrate And Hydrochlorothiazide have a moderate drug interaction according to U.S. FDA drug labeling data. Concomitant use of ACTH with hydrochlorothiazide may cause hypokalemia, which can sensitize the heart to toxic effects of digitalis. The mechanism involves hypokalemia induction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Repository Corticotropin Class
- Adrenocorticotropic Hormone
- Metoprolol Tartrate And Hydrochlorothiazide Class
- Thiazide Diuretic
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Repository Corticotropin and Metoprolol Tartrate And Hydrochlorothiazide occurs because hypokalemia induction. Clinically, this means concomitant use of acth with hydrochlorothiazide may cause hypokalemia, which can sensitize the heart to toxic effects of digitalis. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Repository Corticotropin and your doctor is considering prescribing Metoprolol Tartrate And Hydrochlorothiazide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider