Orlistat has 13 known drug interactions based on U.S. FDA drug labeling data. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Amiodarone, Cyclosporine, Levothyroxine. Patients taking Orlistat should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 13
- Major
- 7
- Moderate
- 2
Major (7)
- Orlistat + Amiodarone— Reduction in exposure to amiodarone and its metabolite observed when coadministered.
- Orlistat + Cyclosporine— Reduction in cyclosporine plasma levels observed with coadministration. Should not be simultaneously coadministered; cyc…
- Orlistat + Levothyroxine— Hypothyroidism reported with concomitant use. Patients should be monitored for changes in thyroid function. Administer a…
- Orlistat + Propafenone— Reduces propafenone concentrations; abrupt cessation has resulted in convulsions, atrioventricular block, and circulator…
- Orlistat + Propafenone Hydrochloride— May reduce propafenone concentrations; abrupt cessation has resulted in convulsions, atrioventricular block, and circula…
- Orlistat + Triheptanoin— Co-administration may reduce exposure to triheptanoin metabolite heptanoate and reduce clinical effect of triheptanoin. …
- Orlistat + Warfarin— Decreased prothrombin, increased INR, and unbalanced anticoagulant treatment reported. Close monitoring of coagulation p…
Moderate (2)
- Orlistat + Alendronate Sodium And Cholecalciferol— Orlistat may impair the absorption of cholecalciferol. Additional vitamin D supplementation should be considered.
- Orlistat + Levothyroxine Sodium— May reduce levothyroxine efficacy by affecting absorption; monitor patients for changes in thyroid function.