Norethindrone And Ethinyl Estradiol has 54 known drug interactions based on U.S. FDA drug labeling data. Of these, 5 are contraindicated combinations that should be avoided entirely. 15 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Dasabuvir, Ombitasvir, Ombitasvir/Paritaprevir/Ritonavir. Patients taking Norethindrone And Ethinyl Estradiol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 54
- Contraindicated
- 5
- Major
- 15
- Moderate
- 33
Contraindicated (5)
- Norethindrone And Ethinyl Estradiol + Dasabuvir— Do not co-administer with norethindrone and ethinyl estradiol as part of HCV drug combinations, due to potential for ALT…
- Norethindrone And Ethinyl Estradiol + Ombitasvir— Do not co-administer norethindrone and ethinyl estradiol with HCV drug combinations containing ombitasvir/paritaprevir/r…
- Norethindrone And Ethinyl Estradiol + Ombitasvir/Paritaprevir/Ritonavir— Do not co-administer with norethindrone and ethinyl estradiol due to potential for ALT elevations and risk of liver enzy…
- Norethindrone And Ethinyl Estradiol + Paritaprevir— Do not co-administer norethindrone and ethinyl estradiol with HCV drug combinations containing ombitasvir/paritaprevir/r…
- Norethindrone And Ethinyl Estradiol + Ritonavir— Do not co-administer with HCV combination therapy containing ombitasvir/paritaprevir/ritonavir due to potential for ALT …
Major (15)
- Norethindrone And Ethinyl Estradiol + Amprenavir— HIV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, pot…
- Norethindrone And Ethinyl Estradiol + Atazanavir— HIV protease inhibitor (in combination with ritonavir) that may increase plasma concentrations of norethindrone and ethi…
- Norethindrone And Ethinyl Estradiol + Boceprevir— HCV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, pot…
- Norethindrone And Ethinyl Estradiol + Colesevelam— Bile acid sequestrant that significantly decreases the AUC of ethinyl estradiol, potentially diminishing contraceptive e…
- Norethindrone And Ethinyl Estradiol + Darunavir— HIV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, pot…
- Norethindrone And Ethinyl Estradiol + Etravirine— Non-nucleoside reverse transcriptase inhibitor that may increase plasma concentrations of norethindrone and ethinyl estr…
- Norethindrone And Ethinyl Estradiol + Fosamprenavir— HIV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, pot…
- Norethindrone And Ethinyl Estradiol + Indinavir— HIV protease inhibitor that may increase plasma concentrations of norethindrone and ethinyl estradiol.
- Norethindrone And Ethinyl Estradiol + Lopinavir— HIV protease inhibitor (in combination with ritonavir) that may decrease plasma concentrations of norethindrone and ethi…
- Norethindrone And Ethinyl Estradiol + Lopinavir And Ritonavir— HIV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, pot…
- Norethindrone And Ethinyl Estradiol + Nelfinavir— HIV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, pot…
- Norethindrone And Ethinyl Estradiol + Nevirapine— Non-nucleoside reverse transcriptase inhibitor that may significantly decrease plasma concentrations of norethindrone an…
- Norethindrone And Ethinyl Estradiol + Rifampin— Reduced efficacy of oral contraceptive with increased breakthrough bleeding and menstrual irregularities.
- Norethindrone And Ethinyl Estradiol + Telaprevir— HCV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, pot…
- Norethindrone And Ethinyl Estradiol + Tipranavir— HIV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, pot…
Moderate (33)
- Norethindrone And Ethinyl Estradiol + Acetaminophen— May increase plasma ethinyl estradiol concentrations.
- Norethindrone And Ethinyl Estradiol + Ampicillin— Possibly associated with reduced contraceptive efficacy and breakthrough bleeding.
- Norethindrone And Ethinyl Estradiol + Aprepitant— Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing c…
- Norethindrone And Ethinyl Estradiol + Ascorbic Acid— May increase plasma ethinyl estradiol concentrations.
- Norethindrone And Ethinyl Estradiol + Atorvastatin— May increase ethinyl estradiol AUC by approximately 20-25% when co-administered.
- Norethindrone And Ethinyl Estradiol + Barbiturates— Enzyme inducers that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing …
- Norethindrone And Ethinyl Estradiol + Bosentan— Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing c…
- Norethindrone And Ethinyl Estradiol + Carbamazepine— Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing c…
- Norethindrone And Ethinyl Estradiol + Cyclosporine— COCs containing ethinyl estradiol may inhibit metabolism of cyclosporine, potentially increasing its plasma concentratio…
- Norethindrone And Ethinyl Estradiol + Felbamate— Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing c…
- Norethindrone And Ethinyl Estradiol + Fluconazole— CYP3A4 inhibitor that may increase plasma hormone concentrations of norethindrone and ethinyl estradiol.
- Norethindrone And Ethinyl Estradiol + Grapefruit Juice— CYP3A4 inhibitor that may increase plasma hormone concentrations of norethindrone and ethinyl estradiol.
- Norethindrone And Ethinyl Estradiol + Griseofulvin— Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing c…
- Norethindrone And Ethinyl Estradiol + Isotretinoin— Study showed isotretinoin did not induce clinically relevant pharmacokinetic changes; however, effectiveness as contrace…
- Norethindrone And Ethinyl Estradiol + Itraconazole— CYP3A4 inhibitor that may increase plasma hormone concentrations of norethindrone and ethinyl estradiol.
- Norethindrone And Ethinyl Estradiol + Ketoconazole— CYP3A4 inhibitor that may increase plasma hormone concentrations of norethindrone and ethinyl estradiol.
- Norethindrone And Ethinyl Estradiol + Lamotrigine— Ethinyl estradiol may decrease plasma concentrations of lamotrigine, potentially reducing seizure control.
- Norethindrone And Ethinyl Estradiol + Oxcarbazepine— Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing c…
- Norethindrone And Ethinyl Estradiol + Phentermine And Topiramate— Co-administration decreased ethinyl estradiol exposure by 16% and increased norethindrone exposure by 22%, potentially c…
- Norethindrone And Ethinyl Estradiol + Phentermine And Topiramate Extended-Release— Co-administration decreases ethinyl estradiol exposure by 16% and increases norethindrone exposure by 22%, potentially c…
- Norethindrone And Ethinyl Estradiol + Phenylbutazone— Associated with reduced contraceptive efficacy and increased breakthrough bleeding.
- Norethindrone And Ethinyl Estradiol + Phenytoin— Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing c…
- Norethindrone And Ethinyl Estradiol + Phenytoin Sodium— Associated with reduced contraceptive efficacy and increased breakthrough bleeding.
- Norethindrone And Ethinyl Estradiol + Prednisolone— COCs containing ethinyl estradiol may inhibit metabolism of prednisolone, potentially increasing its plasma concentratio…
- Norethindrone And Ethinyl Estradiol + Rifabutin— Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing c…
- Norethindrone And Ethinyl Estradiol + Rosuvastatin— May increase ethinyl estradiol AUC by approximately 20-25% when co-administered.
- Norethindrone And Ethinyl Estradiol + Rufinamide— Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing c…
- Norethindrone And Ethinyl Estradiol + St. John'S Wort— Herbal product that induces CYP3A4 and may decrease plasma concentrations of norethindrone and ethinyl estradiol, potent…
- Norethindrone And Ethinyl Estradiol + Tetracycline— Possibly associated with reduced contraceptive efficacy and menstrual irregularities.
- Norethindrone And Ethinyl Estradiol + Theophylline— COCs containing ethinyl estradiol may inhibit metabolism of theophylline, potentially increasing its plasma concentratio…
- Norethindrone And Ethinyl Estradiol + Tizanidine— COCs containing ethinyl estradiol may inhibit metabolism of tizanidine, potentially increasing its plasma concentrations…
- Norethindrone And Ethinyl Estradiol + Topiramate— Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing c…
- Norethindrone And Ethinyl Estradiol + Voriconazole— CYP3A4 inhibitor that may increase plasma hormone concentrations of norethindrone and ethinyl estradiol.