Home›Norethindrone And Ethinyl Estradiol

Norethindrone And Ethinyl Estradiol

Also known as: Wymzya Fe

EstrogenProgestinEstrogen Receptor Agonists

Route: Oral

Check Norethindrone And Ethinyl Estradiol Interactions →

54 interactions on record⛔ Black Box Warning

Norethindrone And Ethinyl Estradiol has 54 known drug interactions based on U.S. FDA drug labeling data. Of these, 5 are contraindicated combinations that should be avoided entirely. 15 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Dasabuvir, Ombitasvir, Ombitasvir/Paritaprevir/Ritonavir. Patients taking Norethindrone And Ethinyl Estradiol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 54
Contraindicated: 5
Major: 15
Moderate: 33

Contraindicated (5)

Norethindrone And Ethinyl Estradiol + Dasabuvir— Do not co-administer with norethindrone and ethinyl estradiol as part of HCV drug combinations, due to potential for ALT…
Norethindrone And Ethinyl Estradiol + Ombitasvir— Do not co-administer norethindrone and ethinyl estradiol with HCV drug combinations containing ombitasvir/paritaprevir/r…
Norethindrone And Ethinyl Estradiol + Ombitasvir/Paritaprevir/Ritonavir— Do not co-administer with norethindrone and ethinyl estradiol due to potential for ALT elevations and risk of liver enzy…
Norethindrone And Ethinyl Estradiol + Paritaprevir— Do not co-administer norethindrone and ethinyl estradiol with HCV drug combinations containing ombitasvir/paritaprevir/r…
Norethindrone And Ethinyl Estradiol + Ritonavir— Do not co-administer with HCV combination therapy containing ombitasvir/paritaprevir/ritonavir due to potential for ALT …

Major (15)

Norethindrone And Ethinyl Estradiol + Amprenavir— HIV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, pot…
Norethindrone And Ethinyl Estradiol + Atazanavir— HIV protease inhibitor (in combination with ritonavir) that may increase plasma concentrations of norethindrone and ethi…
Norethindrone And Ethinyl Estradiol + Boceprevir— HCV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, pot…
Norethindrone And Ethinyl Estradiol + Colesevelam— Bile acid sequestrant that significantly decreases the AUC of ethinyl estradiol, potentially diminishing contraceptive e…
Norethindrone And Ethinyl Estradiol + Darunavir— HIV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, pot…
Norethindrone And Ethinyl Estradiol + Etravirine— Non-nucleoside reverse transcriptase inhibitor that may increase plasma concentrations of norethindrone and ethinyl estr…
Norethindrone And Ethinyl Estradiol + Fosamprenavir— HIV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, pot…
Norethindrone And Ethinyl Estradiol + Indinavir— HIV protease inhibitor that may increase plasma concentrations of norethindrone and ethinyl estradiol.
Norethindrone And Ethinyl Estradiol + Lopinavir— HIV protease inhibitor (in combination with ritonavir) that may decrease plasma concentrations of norethindrone and ethi…
Norethindrone And Ethinyl Estradiol + Lopinavir And Ritonavir— HIV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, pot…
Norethindrone And Ethinyl Estradiol + Nelfinavir— HIV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, pot…
Norethindrone And Ethinyl Estradiol + Nevirapine— Non-nucleoside reverse transcriptase inhibitor that may significantly decrease plasma concentrations of norethindrone an…
Norethindrone And Ethinyl Estradiol + Rifampin— Reduced efficacy of oral contraceptive with increased breakthrough bleeding and menstrual irregularities.
Norethindrone And Ethinyl Estradiol + Telaprevir— HCV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, pot…
Norethindrone And Ethinyl Estradiol + Tipranavir— HIV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, pot…

Moderate (33)

Norethindrone And Ethinyl Estradiol + Acetaminophen— May increase plasma ethinyl estradiol concentrations.
Norethindrone And Ethinyl Estradiol + Ampicillin— Possibly associated with reduced contraceptive efficacy and breakthrough bleeding.
Norethindrone And Ethinyl Estradiol + Aprepitant— Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing c…
Norethindrone And Ethinyl Estradiol + Ascorbic Acid— May increase plasma ethinyl estradiol concentrations.
Norethindrone And Ethinyl Estradiol + Atorvastatin— May increase ethinyl estradiol AUC by approximately 20-25% when co-administered.
Norethindrone And Ethinyl Estradiol + Barbiturates— Enzyme inducers that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing …
Norethindrone And Ethinyl Estradiol + Bosentan— Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing c…
Norethindrone And Ethinyl Estradiol + Carbamazepine— Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing c…
Norethindrone And Ethinyl Estradiol + Cyclosporine— COCs containing ethinyl estradiol may inhibit metabolism of cyclosporine, potentially increasing its plasma concentratio…
Norethindrone And Ethinyl Estradiol + Felbamate— Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing c…
Norethindrone And Ethinyl Estradiol + Fluconazole— CYP3A4 inhibitor that may increase plasma hormone concentrations of norethindrone and ethinyl estradiol.
Norethindrone And Ethinyl Estradiol + Grapefruit Juice— CYP3A4 inhibitor that may increase plasma hormone concentrations of norethindrone and ethinyl estradiol.
Norethindrone And Ethinyl Estradiol + Griseofulvin— Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing c…
Norethindrone And Ethinyl Estradiol + Isotretinoin— Study showed isotretinoin did not induce clinically relevant pharmacokinetic changes; however, effectiveness as contrace…
Norethindrone And Ethinyl Estradiol + Itraconazole— CYP3A4 inhibitor that may increase plasma hormone concentrations of norethindrone and ethinyl estradiol.
Norethindrone And Ethinyl Estradiol + Ketoconazole— CYP3A4 inhibitor that may increase plasma hormone concentrations of norethindrone and ethinyl estradiol.
Norethindrone And Ethinyl Estradiol + Lamotrigine— Ethinyl estradiol may decrease plasma concentrations of lamotrigine, potentially reducing seizure control.
Norethindrone And Ethinyl Estradiol + Oxcarbazepine— Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing c…
Norethindrone And Ethinyl Estradiol + Phentermine And Topiramate— Co-administration decreased ethinyl estradiol exposure by 16% and increased norethindrone exposure by 22%, potentially c…
Norethindrone And Ethinyl Estradiol + Phentermine And Topiramate Extended-Release— Co-administration decreases ethinyl estradiol exposure by 16% and increases norethindrone exposure by 22%, potentially c…
Norethindrone And Ethinyl Estradiol + Phenylbutazone— Associated with reduced contraceptive efficacy and increased breakthrough bleeding.
Norethindrone And Ethinyl Estradiol + Phenytoin— Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing c…
Norethindrone And Ethinyl Estradiol + Phenytoin Sodium— Associated with reduced contraceptive efficacy and increased breakthrough bleeding.
Norethindrone And Ethinyl Estradiol + Prednisolone— COCs containing ethinyl estradiol may inhibit metabolism of prednisolone, potentially increasing its plasma concentratio…
Norethindrone And Ethinyl Estradiol + Rifabutin— Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing c…
Norethindrone And Ethinyl Estradiol + Rosuvastatin— May increase ethinyl estradiol AUC by approximately 20-25% when co-administered.
Norethindrone And Ethinyl Estradiol + Rufinamide— Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing c…
Norethindrone And Ethinyl Estradiol + St. John'S Wort— Herbal product that induces CYP3A4 and may decrease plasma concentrations of norethindrone and ethinyl estradiol, potent…
Norethindrone And Ethinyl Estradiol + Tetracycline— Possibly associated with reduced contraceptive efficacy and menstrual irregularities.
Norethindrone And Ethinyl Estradiol + Theophylline— COCs containing ethinyl estradiol may inhibit metabolism of theophylline, potentially increasing its plasma concentratio…
Norethindrone And Ethinyl Estradiol + Tizanidine— COCs containing ethinyl estradiol may inhibit metabolism of tizanidine, potentially increasing its plasma concentrations…
Norethindrone And Ethinyl Estradiol + Topiramate— Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing c…
Norethindrone And Ethinyl Estradiol + Voriconazole— CYP3A4 inhibitor that may increase plasma hormone concentrations of norethindrone and ethinyl estradiol.

Norethindrone And Ethinyl Estradiol + Dasabuvir⛔Contraindicated

Do not co-administer with norethindrone and ethinyl estradiol as part of HCV drug combinations, due to potential for ALT elevations.

Norethindrone And Ethinyl Estradiol + Ombitasvir⛔Contraindicated

Do not co-administer norethindrone and ethinyl estradiol with HCV drug combinations containing ombitasvir/paritaprevir/ritonavir due to potential for ALT elevations.

Norethindrone And Ethinyl Estradiol + Ombitasvir/Paritaprevir/Ritonavir⛔Contraindicated

Do not co-administer with norethindrone and ethinyl estradiol due to potential for ALT elevations and risk of liver enzyme elevation.

Norethindrone And Ethinyl Estradiol + Paritaprevir⛔Contraindicated

Do not co-administer norethindrone and ethinyl estradiol with HCV drug combinations containing ombitasvir/paritaprevir/ritonavir due to potential for ALT elevations.

Norethindrone And Ethinyl Estradiol + Ritonavir⛔Contraindicated

Do not co-administer with HCV combination therapy containing ombitasvir/paritaprevir/ritonavir due to potential for ALT elevations.

Norethindrone And Ethinyl Estradiol + Amprenavir⚠️Major

HIV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing contraceptive effectiveness.

Norethindrone And Ethinyl Estradiol + Atazanavir⚠️Major

HIV protease inhibitor (in combination with ritonavir) that may increase plasma concentrations of norethindrone and ethinyl estradiol.

Norethindrone And Ethinyl Estradiol + Boceprevir⚠️Major

HCV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing contraceptive effectiveness.

Norethindrone And Ethinyl Estradiol + Colesevelam⚠️Major

Bile acid sequestrant that significantly decreases the AUC of ethinyl estradiol, potentially diminishing contraceptive effectiveness.

Norethindrone And Ethinyl Estradiol + Darunavir⚠️Major

HIV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing contraceptive effectiveness.

Norethindrone And Ethinyl Estradiol + Etravirine⚠️Major

Non-nucleoside reverse transcriptase inhibitor that may increase plasma concentrations of norethindrone and ethinyl estradiol.

Norethindrone And Ethinyl Estradiol + Fosamprenavir⚠️Major

HIV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing contraceptive effectiveness.

Norethindrone And Ethinyl Estradiol + Indinavir⚠️Major

HIV protease inhibitor that may increase plasma concentrations of norethindrone and ethinyl estradiol.

Norethindrone And Ethinyl Estradiol + Lopinavir⚠️Major

HIV protease inhibitor (in combination with ritonavir) that may decrease plasma concentrations of norethindrone and ethinyl estradiol.

Norethindrone And Ethinyl Estradiol + Lopinavir And Ritonavir⚠️Major

HIV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing contraceptive effectiveness.

Norethindrone And Ethinyl Estradiol + Nelfinavir⚠️Major

HIV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing contraceptive effectiveness.

Norethindrone And Ethinyl Estradiol + Nevirapine⚠️Major

Non-nucleoside reverse transcriptase inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing contraceptive effectiveness.

Norethindrone And Ethinyl Estradiol + Rifampin⚠️Major

Reduced efficacy of oral contraceptive with increased breakthrough bleeding and menstrual irregularities.

Norethindrone And Ethinyl Estradiol + Telaprevir⚠️Major

HCV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing contraceptive effectiveness.

Norethindrone And Ethinyl Estradiol + Tipranavir⚠️Major

HIV protease inhibitor that may significantly decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing contraceptive effectiveness.

Norethindrone And Ethinyl Estradiol + Acetaminophen🟡Moderate

May increase plasma ethinyl estradiol concentrations.

Norethindrone And Ethinyl Estradiol + Ampicillin🟡Moderate

Possibly associated with reduced contraceptive efficacy and breakthrough bleeding.

Norethindrone And Ethinyl Estradiol + Aprepitant🟡Moderate

Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing contraceptive effectiveness or increasing breakthrough bleeding.

Norethindrone And Ethinyl Estradiol + Ascorbic Acid🟡Moderate

May increase plasma ethinyl estradiol concentrations.

Norethindrone And Ethinyl Estradiol + Atorvastatin🟡Moderate

May increase ethinyl estradiol AUC by approximately 20-25% when co-administered.

Norethindrone And Ethinyl Estradiol + Barbiturates🟡Moderate

Enzyme inducers that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing contraceptive effectiveness or increasing breakthrough bleeding.

Norethindrone And Ethinyl Estradiol + Bosentan🟡Moderate

Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing contraceptive effectiveness or increasing breakthrough bleeding.

Norethindrone And Ethinyl Estradiol + Carbamazepine🟡Moderate

Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing contraceptive effectiveness or increasing breakthrough bleeding.

Norethindrone And Ethinyl Estradiol + Cyclosporine🟡Moderate

COCs containing ethinyl estradiol may inhibit metabolism of cyclosporine, potentially increasing its plasma concentrations.

Norethindrone And Ethinyl Estradiol + Felbamate🟡Moderate

Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing contraceptive effectiveness or increasing breakthrough bleeding.

Norethindrone And Ethinyl Estradiol + Fluconazole🟡Moderate

CYP3A4 inhibitor that may increase plasma hormone concentrations of norethindrone and ethinyl estradiol.

Norethindrone And Ethinyl Estradiol + Grapefruit Juice🟡Moderate

CYP3A4 inhibitor that may increase plasma hormone concentrations of norethindrone and ethinyl estradiol.

Norethindrone And Ethinyl Estradiol + Griseofulvin🟡Moderate

Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing contraceptive effectiveness or increasing breakthrough bleeding.

Norethindrone And Ethinyl Estradiol + Isotretinoin🟡Moderate

Study showed isotretinoin did not induce clinically relevant pharmacokinetic changes; however, effectiveness as contraception may vary and dual contraception is required.

Norethindrone And Ethinyl Estradiol + Itraconazole🟡Moderate

CYP3A4 inhibitor that may increase plasma hormone concentrations of norethindrone and ethinyl estradiol.

Norethindrone And Ethinyl Estradiol + Ketoconazole🟡Moderate

CYP3A4 inhibitor that may increase plasma hormone concentrations of norethindrone and ethinyl estradiol.

Norethindrone And Ethinyl Estradiol + Lamotrigine🟡Moderate

Ethinyl estradiol may decrease plasma concentrations of lamotrigine, potentially reducing seizure control.

Norethindrone And Ethinyl Estradiol + Oxcarbazepine🟡Moderate

Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing contraceptive effectiveness or increasing breakthrough bleeding.

Norethindrone And Ethinyl Estradiol + Phentermine And Topiramate🟡Moderate

Co-administration decreased ethinyl estradiol exposure by 16% and increased norethindrone exposure by 22%, potentially causing irregular bleeding/spotting.

Norethindrone And Ethinyl Estradiol + Phentermine And Topiramate Extended-Release🟡Moderate

Co-administration decreases ethinyl estradiol exposure by 16% and increases norethindrone exposure by 22%, potentially causing irregular bleeding/spotting due to altered hormone balance.

Norethindrone And Ethinyl Estradiol + Phenylbutazone🟡Moderate

Associated with reduced contraceptive efficacy and increased breakthrough bleeding.

Norethindrone And Ethinyl Estradiol + Phenytoin🟡Moderate

Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing contraceptive effectiveness or increasing breakthrough bleeding.

Norethindrone And Ethinyl Estradiol + Phenytoin Sodium🟡Moderate

Associated with reduced contraceptive efficacy and increased breakthrough bleeding.

Norethindrone And Ethinyl Estradiol + Prednisolone🟡Moderate

COCs containing ethinyl estradiol may inhibit metabolism of prednisolone, potentially increasing its plasma concentrations.

Norethindrone And Ethinyl Estradiol + Rifabutin🟡Moderate

Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing contraceptive effectiveness or increasing breakthrough bleeding.

Norethindrone And Ethinyl Estradiol + Rosuvastatin🟡Moderate

May increase ethinyl estradiol AUC by approximately 20-25% when co-administered.

Norethindrone And Ethinyl Estradiol + Rufinamide🟡Moderate

Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing contraceptive effectiveness or increasing breakthrough bleeding.

Norethindrone And Ethinyl Estradiol + St. John'S Wort🟡Moderate

Herbal product that induces CYP3A4 and may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing contraceptive effectiveness.

Norethindrone And Ethinyl Estradiol + Tetracycline🟡Moderate

Possibly associated with reduced contraceptive efficacy and menstrual irregularities.

Norethindrone And Ethinyl Estradiol + Theophylline🟡Moderate

COCs containing ethinyl estradiol may inhibit metabolism of theophylline, potentially increasing its plasma concentrations.

Norethindrone And Ethinyl Estradiol + Tizanidine🟡Moderate

COCs containing ethinyl estradiol may inhibit metabolism of tizanidine, potentially increasing its plasma concentrations.

Norethindrone And Ethinyl Estradiol + Topiramate🟡Moderate

Enzyme inducer that may decrease plasma concentrations of norethindrone and ethinyl estradiol, potentially diminishing contraceptive effectiveness or increasing breakthrough bleeding.

Norethindrone And Ethinyl Estradiol + Voriconazole🟡Moderate

CYP3A4 inhibitor that may increase plasma hormone concentrations of norethindrone and ethinyl estradiol.

Norethindrone And Ethinyl Estradiol + Temazepamℹ️Unknown

COCs have been shown to decrease plasma concentrations of acetaminophen, clofibric acid, morphine, salicylic acid, temazepam and lamotrigine.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.