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Doxazosin Mesylate

Also known as: Doxazosin

Route: Oral

14 interactions on record

Doxazosin Mesylate has 14 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Mao Inhibitors, Atazanavir, Clarithromycin. Patients taking Doxazosin Mesylate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 14
Major: 1
Moderate: 12
Minor: 1

Major (1)

Doxazosin Mesylate + Mao Inhibitors— Concomitant administration can result in additive blood pressure lowering effects and symptomatic hypotension.

Moderate (12)

Doxazosin Mesylate + Atazanavir— Caution should be exercised when concomitantly administering CARDURA XL with a strong CYP 3A4 inhibitor, such as atazana…
Doxazosin Mesylate + Clarithromycin— Caution should be exercised when concomitantly administering CARDURA XL with a strong CYP 3A4 inhibitor, such as atazana…
Doxazosin Mesylate + Doxazosin— 7 DRUG INTERACTIONS Strong cytochrome P450 (CYP) 3A inhibitors may increase exposure to doxazosin and increased risk of …
Doxazosin Mesylate + Indinavir— Caution should be exercised when concomitantly administering CARDURA XL with a strong CYP 3A4 inhibitor, such as atazana…
Doxazosin Mesylate + Itraconazole— Caution should be exercised when concomitantly administering CARDURA XL with a strong CYP 3A4 inhibitor, such as atazana…
Doxazosin Mesylate + Ketoconazole— Caution should be exercised when concomitantly administering CARDURA XL with a strong CYP 3A4 inhibitor, such as atazana…
Doxazosin Mesylate + Nefazodone— Strong CYP 3A4 inhibitor; caution should be exercised when concomitantly administering with doxazosin mesylate.
Doxazosin Mesylate + Nelfinavir— Caution should be exercised when concomitantly administering CARDURA XL with a strong CYP 3A4 inhibitor, such as atazana…
Doxazosin Mesylate + Ritonavir— Caution should be exercised when concomitantly administering CARDURA XL with a strong CYP 3A4 inhibitor, such as atazana…
Doxazosin Mesylate + Saquinavir— Caution should be exercised when concomitantly administering CARDURA XL with a strong CYP 3A4 inhibitor, such as atazana…
Doxazosin Mesylate + Telithromycin— Caution should be exercised when concomitantly administering CARDURA XL with a strong CYP 3A4 inhibitor, such as atazana…
Doxazosin Mesylate + Voriconazole— Caution should be exercised when concomitantly administering CARDURA XL with a strong CYP 3A4 inhibitor, such as atazana…

Minor (1)

Doxazosin Mesylate + Cimetidine— Cimetidine administration resulted in 10% increase in doxazosin AUC with slight but not significant increases in Cmax an…

Doxazosin Mesylate + Mao Inhibitors⚠️Major

Concomitant administration can result in additive blood pressure lowering effects and symptomatic hypotension.

Doxazosin Mesylate + Atazanavir🟡Moderate

Caution should be exercised when concomitantly administering CARDURA XL with a strong CYP 3A4 inhibitor, such as atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, or voriconazole [see Clinical Pharmacology (12.3) ] .

Doxazosin Mesylate + Clarithromycin🟡Moderate

Doxazosin Mesylate + Doxazosin🟡Moderate

7 DRUG INTERACTIONS Strong cytochrome P450 (CYP) 3A inhibitors may increase exposure to doxazosin and increased risk of hypotension. ( 7.1 ) Concomitant administration of doxazosin tablets with a phosphodiesterase-5 (PDE-5) inhibitor can result in additive blood pressure lowering effects and symptomatic hypotension. ( 7.2 ) 7.1 CYP3A Inhibitors In vitro studies suggest that doxazosin is a substrate of CYP3A4.

Doxazosin Mesylate + Indinavir🟡Moderate

Doxazosin Mesylate + Itraconazole🟡Moderate

Doxazosin Mesylate + Ketoconazole🟡Moderate

Doxazosin Mesylate + Nefazodone🟡Moderate

Strong CYP 3A4 inhibitor; caution should be exercised when concomitantly administering with doxazosin mesylate.

Doxazosin Mesylate + Nelfinavir🟡Moderate

Doxazosin Mesylate + Ritonavir🟡Moderate

Doxazosin Mesylate + Saquinavir🟡Moderate

Doxazosin Mesylate + Telithromycin🟡Moderate

Doxazosin Mesylate + Voriconazole🟡Moderate

Doxazosin Mesylate + Cimetidine🟢Minor

Cimetidine administration resulted in 10% increase in doxazosin AUC with slight but not significant increases in Cmax and half-life.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.