Nonabsorbable antacids given concurrently may inhibit the desired lactulose-induced drop in colonic pH, potentially reducing treatment efficacy.
Source: NLP:lactulose solution usp, 10 g/15 ml
Lactulose Solution Usp, 10 G/15 Ml Interactions
Brand names: Lactulose Solution
Osmotic Laxative · Osmotic Activity · Acidifying Activity
Route: Oral, Rectal
Contraindications
CONTRAINDICATIONS Since lactulose solution contains galactose (less than 1.6 g/15 mL), it is contraindicated in patients who require a low galactose diet.
Pregnancy & Breastfeeding
Pregnancy: Teratogenic Effects; Pregnancy Category B. Reproduction studies have been performed in mice, rats, and rabbits at doses up to 2 or 4 times the usual human oral dose and have revealed no evidence of impaired fertility or harm to the fetus due to lactulose. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
4 interactions on record
Anti-infective agents may eliminate colonic bacteria and interfere with desired degradation of lactulose and acidification of colonic contents.
Source: NLP:lactulose solution usp, 10 g/15 ml
Other laxatives should not be used concurrently, especially during initial phase of portal-systemic encephalopathy therapy, as loose stools may falsely suggest adequate lactulose dosage.
Source: NLP:lactulose solution usp, 10 g/15 ml
Elimination of colonic bacteria by neomycin may interfere with lactulose degradation and prevent acidification of colonic contents. Patient status should be closely monitored.
Source: NLP:lactulose solution usp, 10 g/15 ml