Enflurane has 11 known drug interactions based on U.S. FDA drug labeling data. 8 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Dexmethylphenidate Hydrochloride, Dopamine Hydrochloride, Methylphenidate Hydrochloride. Patients taking Enflurane should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 11
- Major
- 8
- Moderate
- 3
Major (8)
- Enflurane + Dexmethylphenidate Hydrochloride— Concomitant use may increase risk of sudden blood pressure and heart rate increase during surgery. Avoid use on day of s…
- Enflurane + Dopamine Hydrochloride— Concomitant use may increase cardiac autonomic irritability and sensitize the myocardium to dopamine, potentially leadin…
- Enflurane + Methylphenidate Hydrochloride— Concomitant use may increase risk of sudden blood pressure and heart rate increase during surgery. Avoid use on day of s…
- Enflurane + Methylphenidate Hydrochloride Extended Release— Concomitant use may increase risk of sudden blood pressure and heart rate increase during surgery. Avoid on day of surge…
- Enflurane + Norepinephrine Bitartrate— Concomitant use may lead to ventricular tachycardia or ventricular fibrillation. Monitor cardiac rhythm.
- Enflurane + Propofol— Increases anesthetic/sedative and cardiorespiratory effects of propofol during maintenance anesthesia. Concurrent use is…
- Enflurane + Rocuronium Bromide— Enhances neuromuscular blocking activity and prolongs duration of rocuronium bromide action by 20-37% and decreases infu…
- Enflurane + Vecuronium Bromide— Enflurane enhances vecuronium-induced neuromuscular blockade. Potentiation is most prominent with enflurane use.
Moderate (3)
- Enflurane + Atracurium Besylate— May enhance the neuromuscular blocking action of atracurium.
- Enflurane + Propofol Injectable Emulsion— Concurrent administration during maintenance can increase anesthetic/sedative and cardiorespiratory effects of propofol.
- Enflurane + Rocuronium— Enflurane enhances rocuronium activity, prolonging neuromuscular block duration and decreasing infusion requirements by …