Ephedrine has 14 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Tranylcypromine Sulfate, Droxidopa, Midodrine Hydrochloride. Patients taking Ephedrine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 14
- Contraindicated
- 1
- Major
- 4
- Moderate
- 8
- Minor
- 1
Contraindicated (1)
- Ephedrine + Tranylcypromine Sulfate— Sympathomimetic vasopressor contraindicated; avoid or emergency use only with tranylcypromine discontinuation and monito…
Major (4)
- Ephedrine + Droxidopa— Concomitant use may increase risk for supine hypertension due to additive blood pressure-raising effects.
- Ephedrine + Midodrine Hydrochloride— Increases risk of hypertension when used concomitantly with midodrine. Avoid concomitant use or monitor blood pressure c…
- Ephedrine + Prednisolone Sodium Phosphate— CYP 3A4 inducer enhances metabolism of prednisolone, requiring increased dosage of corticosteroid.
- Ephedrine + Selegiline Hydrochloride— One case of hypertensive crisis reported in patient taking recommended doses of selegiline and ephedrine.
Moderate (8)
- Ephedrine + Dexamethasone— Ephedrine may enhance metabolic clearance of dexamethasone, resulting in decreased blood levels and requiring dosage inc…
- Ephedrine + Dexamethasone 1.5 Mg— Ephedrine may enhance metabolic clearance of dexamethasone, resulting in decreased blood levels and reduced efficacy.
- Ephedrine + Dexamethasone Intensol— Ephedrine enhances metabolic clearance of dexamethasone, resulting in decreased blood levels and requiring dosage increa…
- Ephedrine + Histamine Phosphate— Parenteral beta 2 agonist that decreases allergen-induced wheal and may reduce whealing capacity to histamine.
- Ephedrine + Iobenguane I-123— Sympathomimetic amine that may decrease norepinephrine uptake and cause false negative imaging results with iobenguane.
- Ephedrine + Prednisone— Induces hepatic metabolism of corticosteroids, requiring increased prednisone dosage.
- Ephedrine + Sodium Chloride, Sodium Lactate, Potassium Chloride, Calcium Chloride And Dextrose Monohydrate— Renal clearance of alkaline sympathomimetics like ephedrine may be decreased due to alkalinizing action of lactate.
- Ephedrine + Triamcinolone Acetonide— Induces hepatic microsomal drug metabolizing enzyme activity, enhancing corticosteroid metabolism and requiring increase…
Minor (1)
- Ephedrine + Tolcapone— Tolcapone did not influence ephedrine's effects on hemodynamic parameters or plasma catecholamine levels; drugs can be c…