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Insulin Glulisine

Also known as: Apidra, Apidra Solostar

Insulin Analog

Route: Intravenous, Subcutaneous

34 interactions on record

Insulin Glulisine has 34 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Albuterol, Alcohol, Angiotensin Ii. Patients taking Insulin Glulisine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 34
Moderate: 32

Moderate (32)

Insulin Glulisine + Albuterol— Sympathomimetic agent may decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may b…
Insulin Glulisine + Alcohol— May increase or decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required…
Insulin Glulisine + Angiotensin Ii— May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.
Insulin Glulisine + Barbituric Acid Derivatives— May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.
Insulin Glulisine + Clonidine— May increase or decrease blood glucose lowering effect and may blunt signs/symptoms of hypoglycemia. Dose adjustment and…
Insulin Glulisine + Corticosteroids— May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.
Insulin Glulisine + Danazol— May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.
Insulin Glulisine + Disopyramide— May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.
Insulin Glulisine + Diuretics— May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.
Insulin Glulisine + Epinephrine— Sympathomimetic agent may decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may b…
Insulin Glulisine + Estrogens— May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.
Insulin Glulisine + Fibrates— May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.
Insulin Glulisine + Fluoxetine— May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.
Insulin Glulisine + Glucagon— May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.
Insulin Glulisine + Guanethidine— May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring may be required.
Insulin Glulisine + Isoniazid— May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.
Insulin Glulisine + Lithium— May increase or decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required…
Insulin Glulisine + Macrolide Antibiotics— May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.
Insulin Glulisine + Mao Inhibitors— May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.
Insulin Glulisine + Monoamine Oxidase Inhibitors (Maois)— May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.
Insulin Glulisine + Niacin— May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.
Insulin Glulisine + Nonselective Beta-Adrenergic Antagonists— May increase or decrease blood glucose lowering effect and may blunt signs/symptoms of hypoglycemia. Dose adjustment and…
Insulin Glulisine + Octreotide— Somatostatin analog may increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.
Insulin Glulisine + Pentamidine— May cause hypoglycemia which may sometimes be followed by hyperglycemia. Dose adjustment and increased glucose monitorin…
Insulin Glulisine + Pentoxifylline— May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.
Insulin Glulisine + Pramlintide— May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.
Insulin Glulisine + Protease Inhibitors— May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.
Insulin Glulisine + Reserpine— May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring may be required.
Insulin Glulisine + Salicylates— May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.
Insulin Glulisine + Somatropin— May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.
Insulin Glulisine + Terbutaline— Sympathomimetic agent may decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may b…
Insulin Glulisine + Thyroid Hormones— May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Albuterol🟡Moderate

Sympathomimetic agent may decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Alcohol🟡Moderate

May increase or decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Angiotensin Ii🟡Moderate

May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Barbituric Acid Derivatives🟡Moderate

May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Clonidine🟡Moderate

May increase or decrease blood glucose lowering effect and may blunt signs/symptoms of hypoglycemia. Dose adjustment and increased glucose monitoring required.

Insulin Glulisine + Corticosteroids🟡Moderate

May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Danazol🟡Moderate

May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Disopyramide🟡Moderate

May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Diuretics🟡Moderate

May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Epinephrine🟡Moderate

Sympathomimetic agent may decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Estrogens🟡Moderate

May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Fibrates🟡Moderate

May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Fluoxetine🟡Moderate

May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Glucagon🟡Moderate

May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Guanethidine🟡Moderate

May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring may be required.

Insulin Glulisine + Isoniazid🟡Moderate

May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Lithium🟡Moderate

May increase or decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Macrolide Antibiotics🟡Moderate

May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Mao Inhibitors🟡Moderate

May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Monoamine Oxidase Inhibitors (Maois)🟡Moderate

May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Niacin🟡Moderate

May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Nonselective Beta-Adrenergic Antagonists🟡Moderate

May increase or decrease blood glucose lowering effect and may blunt signs/symptoms of hypoglycemia. Dose adjustment and increased glucose monitoring required.

Insulin Glulisine + Octreotide🟡Moderate

Somatostatin analog may increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Pentamidine🟡Moderate

May cause hypoglycemia which may sometimes be followed by hyperglycemia. Dose adjustment and increased glucose monitoring required.

Insulin Glulisine + Pentoxifylline🟡Moderate

May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Pramlintide🟡Moderate

May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Protease Inhibitors🟡Moderate

May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Reserpine🟡Moderate

May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring may be required.

Insulin Glulisine + Salicylates🟡Moderate

May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Somatropin🟡Moderate

May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Terbutaline🟡Moderate

Sympathomimetic agent may decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Thyroid Hormones🟡Moderate

May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Insulin Glulisine + Acetazolamideℹ️Unknown

7 DRUG INTERACTIONS Table 6: Clinically Significant Drug Interactions with APIDRA Drugs that May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics.

Insulin Glulisine + Somatostatinℹ️Unknown

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.