Ergonovine has 4 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Itraconazole, Ketoconazole, Dopamine Hydrochloride. Patients taking Ergonovine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 4
- Contraindicated
- 2
- Major
- 2
Contraindicated (2)
- Ergonovine + Itraconazole— Coadministration is contraindicated. Itraconazole increases plasma concentrations of ergot alkaloids, potentially increa…
- Ergonovine + Ketoconazole— Coadministration of ketoconazole with ergometrine is contraindicated.
Major (2)
- Ergonovine + Dopamine Hydrochloride— Vasoconstrictor agent; concomitant use with dopamine may result in severe hypertension.
- Ergonovine + Ephedrine Sulfate— Serious postpartum hypertension and stroke reported with concurrent vasopressor and oxytocic use. Carefully monitor bloo…