Sedating Antihistamines has 11 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Tranylcypromine, Tranylcypromine Sulfate, Buprenorphine. Patients taking Sedating Antihistamines should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 11
- Contraindicated
- 2
- Major
- 6
- Moderate
- 3
Contraindicated (2)
- Sedating Antihistamines + Tranylcypromine— Non-selective H1 receptor antagonists are contraindicated with tranylcypromine.
- Sedating Antihistamines + Tranylcypromine Sulfate— Contraindicated due to increased anticholinergic effects.
Major (6)
- Sedating Antihistamines + Buprenorphine— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
- Sedating Antihistamines + Buprenorphine And Naloxone— CNS depressant effects increase risk of respiratory depression, profound sedation, coma, and death.
- Sedating Antihistamines + Buprenorphine Hydrochloride— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
- Sedating Antihistamines + Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate— Increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.
- Sedating Antihistamines + Scolopamine Transdermal System— Concurrent use may potentiate CNS adverse reactions including drowsiness, dizziness, and disorientation.
- Sedating Antihistamines + Scopolamine— Concurrent use may potentiate CNS adverse reactions and increase risk of intestinal obstruction and urinary retention. M…
Moderate (3)
- Sedating Antihistamines + Doxepin— Sedative effects of sedating antihistamines may be potentiated when taken with doxepin.
- Sedating Antihistamines + Doxepin Hydrochloride— Sedative effects of sedating antihistamines may be potentiated when taken with doxepin.
- Sedating Antihistamines + Perampanel— CNS depressants that may increase CNS depression when used with FYCOMPA. Patients should limit activity until experience…