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Erythromycin Ethylsuccinate

Also known as: E.E.S 400, E.E.S

Route: Oral

Check Erythromycin Ethylsuccinate Interactions →

15 interactions on record

Erythromycin Ethylsuccinate has 15 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 10 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Dihydroergotamine, Ergotamine, Alprazolam. Patients taking Erythromycin Ethylsuccinate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 15
Contraindicated: 2
Major: 10

Contraindicated (2)

Erythromycin Ethylsuccinate + Dihydroergotamine— Coadministration associated with acute ergot toxicity characterized by vasospasm and ischemia of extremities and central…
Erythromycin Ethylsuccinate + Ergotamine— Coadministration associated with acute ergot toxicity characterized by vasospasm and ischemia of extremities and central…

Major (10)

Erythromycin Ethylsuccinate + Alprazolam— Related benzodiazepine whose effect may be increased by erythromycin.
Erythromycin Ethylsuccinate + Digoxin— Coadministration has been reported to result in elevated digoxin serum levels.
Erythromycin Ethylsuccinate + Lovastatin— Erythromycin has been reported to increase concentrations of lovastatin, an HMG-CoA reductase inhibitor.
Erythromycin Ethylsuccinate + Mao Inhibitors— Erythromycin increases concentrations of HMG-CoA reductase inhibitors.
Erythromycin Ethylsuccinate + Midazolam— Erythromycin has been reported to decrease clearance of midazolam and may increase its pharmacologic effect.
Erythromycin Ethylsuccinate + Oral Anticoagulants— Increased anticoagulant effects have been reported with concomitant use, particularly in elderly patients.
Erythromycin Ethylsuccinate + Simvastatin— Erythromycin has been reported to increase concentrations of simvastatin, an HMG-CoA reductase inhibitor.
Erythromycin Ethylsuccinate + Theophylline— Erythromycin may increase serum theophylline levels, potentially causing toxicity. Theophylline may decrease erythromyci…
Erythromycin Ethylsuccinate + Triazolam— Erythromycin decreases clearance of triazolam and may increase its pharmacologic effect.
Erythromycin Ethylsuccinate + Verapamil— Concurrent verapamil use has been associated with hypotension, bradyarrhythmias, and lactic acidosis.

Erythromycin Ethylsuccinate + Dihydroergotamine⛔Contraindicated

Coadministration associated with acute ergot toxicity characterized by vasospasm and ischemia of extremities and central nervous system.

Erythromycin Ethylsuccinate + Ergotamine⛔Contraindicated

Coadministration associated with acute ergot toxicity characterized by vasospasm and ischemia of extremities and central nervous system.

Erythromycin Ethylsuccinate + Alprazolam⚠️Major

Related benzodiazepine whose effect may be increased by erythromycin.

Erythromycin Ethylsuccinate + Digoxin⚠️Major

Coadministration has been reported to result in elevated digoxin serum levels.

Erythromycin Ethylsuccinate + Lovastatin⚠️Major

Erythromycin has been reported to increase concentrations of lovastatin, an HMG-CoA reductase inhibitor.

Erythromycin Ethylsuccinate + Mao Inhibitors⚠️Major

Erythromycin increases concentrations of HMG-CoA reductase inhibitors.

Erythromycin Ethylsuccinate + Midazolam⚠️Major

Erythromycin has been reported to decrease clearance of midazolam and may increase its pharmacologic effect.

Erythromycin Ethylsuccinate + Oral Anticoagulants⚠️Major

Increased anticoagulant effects have been reported with concomitant use, particularly in elderly patients.

Erythromycin Ethylsuccinate + Simvastatin⚠️Major

Erythromycin has been reported to increase concentrations of simvastatin, an HMG-CoA reductase inhibitor.

Erythromycin Ethylsuccinate + Theophylline⚠️Major

Erythromycin may increase serum theophylline levels, potentially causing toxicity. Theophylline may decrease erythromycin concentrations by ~35%, resulting in subtherapeutic erythromycin levels.

Erythromycin Ethylsuccinate + Triazolam⚠️Major

Erythromycin decreases clearance of triazolam and may increase its pharmacologic effect.

Erythromycin Ethylsuccinate + Verapamil⚠️Major

Concurrent verapamil use has been associated with hypotension, bradyarrhythmias, and lactic acidosis.

Erythromycin Ethylsuccinate + Disopyramideℹ️Unknown

(See Viagra package insert.) There have been spontaneous or published reports of CYP3A based interactions of erythromycin with cyclosporine, carbamazepine, tacrolimus, alfentanil, disopyramide, rifabutin, quinidine, methylprednisolone, cilostazol, vinblastine, and bromocriptine.

Erythromycin Ethylsuccinate + Erythromycinℹ️Unknown

Drug Interactions Theophylline Erythromycin use in patients who are receiving high doses of theophylline may be associated with an increase in serum theophylline levels and potential theophylline toxicity. In case of theophylline toxicity and/or elevated serum theophylline levels, the dose of theophylline should be reduced while the patient is receiving concomitant erythromycin therapy. There have been published reports suggesting that when oral erythromycin is given concurrently with theophylline there is a decrease in erythromycin serum concentrations of approximately 35%.

Erythromycin Ethylsuccinate + Methylprednisoloneℹ️Unknown

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.