Estazolam has 28 known drug interactions based on U.S. FDA drug labeling data. Of these, 4 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Darunavir, Darunavir 600 Mg, Itraconazole. Patients taking Estazolam should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 28
- Contraindicated
- 4
- Major
- 1
- Moderate
- 14
Contraindicated (4)
- Estazolam + Darunavir— Sedatives/hypnotics: orally administered midazolam, triazolam metabolized by CYP3A e.g., buspirone, diazepam, estazolam,…
- Estazolam + Darunavir 600 Mg— buspirone, diazepam, estazolam, zolpidem parenterally administered midazolam ↑ midazolam ↑ triazolam ↑ sedatives/hypnoti…
- Estazolam + Itraconazole— Very potent CYP3A inhibitor; estazolam should be avoided in patients receiving itraconazole.
- Estazolam + Ketoconazole— Very potent CYP3A inhibitor; estazolam should be avoided in patients receiving ketoconazole.
Major (1)
- Estazolam + Alcohol— Potentiates benzodiazepine action and increases CNS depression risk.
Moderate (14)
- Estazolam + Antihistamines— May potentiate the action of estazolam; careful consideration of CNS effects needed.
- Estazolam + Barbiturates— Potent CYP3A inducers expected to decrease estazolam concentrations; also produce CNS depression that may potentiate ben…
- Estazolam + Carbamazepine— Potent CYP3A inducer; expected to decrease estazolam concentrations and reduce efficacy.
- Estazolam + Cimetidine— Significant CYP3A inhibitor; estazolam should be used with caution and appropriate dosage reduction may be needed.
- Estazolam + Diltiazem— Significant CYP3A inhibitor; estazolam should be used with caution and appropriate dosage reduction may be needed.
- Estazolam + Fluvoxamine— Significant CYP3A inhibitor; estazolam should be used with caution and appropriate dosage reduction may be needed.
- Estazolam + Isoniazid— Significant CYP3A inhibitor; estazolam should be used with caution and appropriate dosage reduction may be needed.
- Estazolam + Macrolide Antibiotics— Some macrolide antibiotics are significant CYP3A inhibitors; estazolam should be used with caution and appropriate dosag…
- Estazolam + Monoamine Oxidase Inhibitors (Maois)— May potentiate the action of estazolam; careful consideration of CNS effects needed.
- Estazolam + Nefazodone— Significant CYP3A inhibitor; estazolam should be used with caution and appropriate dosage reduction may be needed.
- Estazolam + Oral Anticoagulants— May potentiate the action of estazolam; careful consideration of CNS effects needed.
- Estazolam + Phenothiazines— May potentiate the action of estazolam; careful consideration of CNS effects needed.
- Estazolam + Phenytoin— Potent CYP3A inducer; expected to decrease estazolam concentrations and reduce efficacy.
- Estazolam + Rifampin— Potent CYP3A inducer; expected to decrease estazolam concentrations and reduce efficacy.