Estrone has 3 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Phenobarbital Sodium, Pentobarbital Sodium, Phenobarbital. Patients taking Estrone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 3
Major: 1
Moderate: 2

Major (1)

Estrone + Phenobarbital Sodium— Phenobarbital may decrease the effect of estrone through induction of hepatic microsomal enzymes.

Moderate (2)

Estrone + Pentobarbital Sodium— Pretreatment with or concurrent barbiturate administration may decrease estrone effects.
Estrone + Phenobarbital— Phenobarbital may decrease the effect of estrone by increasing its metabolism.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.