Meloxicam has 15 known drug interactions based on U.S. FDA drug labeling data. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Angiotensin Ii, Aspirin, Lithium. Patients taking Meloxicam should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 15
- Major
- 6
- Moderate
- 7
Major (6)
- Meloxicam + Angiotensin Ii— NSAIDs may diminish antihypertensive effects and result in renal function deterioration or acute renal failure in elderl…
- Meloxicam + Aspirin— Increased incidence of GI adverse reactions and increased risk of bleeding when combined with meloxicam.
- Meloxicam + Lithium— Increases lithium plasma levels and AUC by 21%, increasing risk of lithium toxicity.
- Meloxicam + Mao Inhibitors— NSAIDs may diminish antihypertensive effects and result in renal function deterioration or acute renal failure in elderl…
- Meloxicam + Methotrexate— Meloxicam may reduce methotrexate elimination, thereby enhancing methotrexate toxicity.
- Meloxicam + Warfarin— Synergistic effect on bleeding with increased risk of serious bleeding compared to either drug alone.
Moderate (7)
- Meloxicam + Andthiazide— NSAIDs can reduce the natriuretic and antihypertensive effects of thiazide diuretics. Monitor diuretic efficacy.
- Meloxicam + Cyclosporine— May affect renal prostaglandins, altering renal toxicity of cyclosporine.
- Meloxicam + Furosemide— In such high risk patients, monitor for signs of worsening renal function (7) Diuretics : NSAIDs can reduce natriuretic …
- Meloxicam + Nonselective Beta-Adrenergic Antagonists— Concomitant use with meloxicam may diminish the antihypertensive effect of beta-blockers. Monitor blood pressure.
- Meloxicam + Propranolol— NSAIDs may diminish the antihypertensive effect; in elderly or volume-depleted patients, may result in deterioration of …
- Meloxicam + Selective Serotonin Reuptake Inhibitors (Ssri)— Concomitant use may potentiate bleeding risk more than NSAID alone; monitor for signs of bleeding.
- Meloxicam + Thiazides— NSAIDs may reduce natriuretic effect; monitor closely for renal failure and ensure diuretic efficacy during concomitant …