Meloxicam has 15 known drug interactions based on U.S. FDA drug labeling data. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetylsalicylic Acid, Angiotensin Ii, Lithium. Patients taking Meloxicam should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 15
- Major
- 6
- Moderate
- 7
Major (6)
- Meloxicam + Acetylsalicylic Acid— Increased incidence of GI adverse reactions and increased risk of bleeding when combined with meloxicam.
- Meloxicam + Angiotensin Ii— NSAIDs may diminish antihypertensive effects and result in renal function deterioration or acute renal failure in elderl…
- Meloxicam + Lithium— Increases lithium plasma levels and AUC by 21%, increasing risk of lithium toxicity.
- Meloxicam + Mao Inhibitors— NSAIDs may diminish antihypertensive effects and result in renal function deterioration or acute renal failure in elderl…
- Meloxicam + Methotrexate— Meloxicam may reduce methotrexate elimination, thereby enhancing methotrexate toxicity.
- Meloxicam + Warfarin— Synergistic effect on bleeding with increased risk of serious bleeding compared to either drug alone.
Moderate (7)
- Meloxicam + Andthiazide— NSAIDs can reduce the natriuretic and antihypertensive effects of thiazide diuretics. Monitor diuretic efficacy.
- Meloxicam + Cyclosporine— May affect renal prostaglandins, altering renal toxicity of cyclosporine.
- Meloxicam + Furosemide— In such high risk patients, monitor for signs of worsening renal function (7) Diuretics : NSAIDs can reduce natriuretic …
- Meloxicam + Nonselective Beta-Adrenergic Antagonists— Concomitant use with meloxicam may diminish the antihypertensive effect of beta-blockers. Monitor blood pressure.
- Meloxicam + Propranolol— NSAIDs may diminish the antihypertensive effect; in elderly or volume-depleted patients, may result in deterioration of …
- Meloxicam + Selective Serotonin Reuptake Inhibitors (Ssri)— Concomitant use may potentiate bleeding risk more than NSAID alone; monitor for signs of bleeding.
- Meloxicam + Thiazides— NSAIDs may reduce natriuretic effect; monitor closely for renal failure and ensure diuretic efficacy during concomitant …