Trimetrexate has 2 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Sepiapterin, Itraconazole. Patients taking Trimetrexate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 2
- Contraindicated
- 1
- Major
- 1
Contraindicated (1)
- Trimetrexate + Sepiapterin— DHFR inhibitor that may reduce sepiapterin metabolism to tetrahydrobiopterin (BH4). Avoid concomitant use.
Major (1)
- Trimetrexate + Itraconazole— Itraconazole increases trimetrexate concentrations. Monitor for adverse reactions; concomitant drug dose reduction may b…