Lithium Carbonate has 41 known drug interactions based on U.S. FDA drug labeling data. 20 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acidifying Agents, Angiotensin Ii, Calcium Channel Blockers. Patients taking Lithium Carbonate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 41
- Major
- 20
- Moderate
- 18
Major (20)
- Lithium Carbonate + Acidifying Agents— Increased risk of serotonin syndrome when co-administered with lithium. Monitor for signs and symptoms; consider discont…
- Lithium Carbonate + Angiotensin Ii— Concomitant use increases steady-state serum lithium concentrations, requiring frequent monitoring and dosage adjustment…
- Lithium Carbonate + Calcium Channel Blockers— Concurrent use may increase neurotoxicity risk (ataxia, tremors, nausea, vomiting, diarrhea, tinnitus). Close monitoring…
- Lithium Carbonate + Captopril— May substantially increase steady-state plasma lithium levels, sometimes resulting in lithium toxicity.
- Lithium Carbonate + Carbamazepine— Concomitant use may increase risk of adverse reactions with carbamazepine.
- Lithium Carbonate + Celecoxib— Increases mean steady-state lithium plasma levels approximately 17%; lithium toxicity has been reported from NSAID-lithi…
- Lithium Carbonate + Diuretics— Diuretic-induced sodium loss reduces lithium clearance and increases serum lithium concentrations, requiring frequent mo…
- Lithium Carbonate + Enalapril— May substantially increase steady-state plasma lithium levels, sometimes resulting in lithium toxicity.
- Lithium Carbonate + Haloperidol— Combined use may cause encephalopathic syndrome with neurological toxicity, weakness, lethargy, fever, tremor, confusion…
- Lithium Carbonate + Indomethacin— Significantly increases steady-state plasma lithium concentrations, with risk of lithium toxicity.
- Lithium Carbonate + Losartan— May substantially increase steady-state plasma lithium levels, sometimes resulting in lithium toxicity.
- Lithium Carbonate + Mao Inhibitors— ACE inhibitor-induced sodium loss may increase serum lithium concentrations, increasing toxicity risk. Requires dose red…
- Lithium Carbonate + Methyldopa— Concomitant use may increase risk of adverse reactions with methyldopa.
- Lithium Carbonate + Metronidazole— May provoke lithium toxicity due to reduced renal clearance; requires close monitoring.
- Lithium Carbonate + Monoamine Oxidase Inhibitors (Maois)— Concomitant administration can precipitate serotonin syndrome. Monitor for signs and symptoms, particularly during lithi…
- Lithium Carbonate + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)— NSAIDs decrease renal blood flow, resulting in decreased renal clearance and increased serum lithium concentrations.
- Lithium Carbonate + Phenytoin— Concomitant use may increase risk of adverse reactions with phenytoin.
- Lithium Carbonate + Piroxicam— Significantly increases steady-state plasma lithium concentrations, with risk of lithium toxicity.
- Lithium Carbonate + Selective Serotonin Reuptake Inhibitors (Ssri)— Concomitant administration can precipitate serotonin syndrome. Monitor for signs and symptoms, particularly during lithi…
- Lithium Carbonate + Succinylcholine Chloride— May enhance the neuromuscular blocking action of succinylcholine.
Moderate (18)
- Lithium Carbonate + Acetazolamide— Examples: metronidazole Acetazolamide, Urea, Xanthine Preparations, Alkalinizing Agents Clinical Impact: Concomitant use…
- Lithium Carbonate + Adrenergic Blockers— Lithium may prolong the effects of neuromuscular blocking agents, requiring cautious use and close monitoring.
- Lithium Carbonate + Alkalinizing Agents— Concomitant use can lower serum lithium concentrations by increasing urinary lithium excretion. Frequent monitoring and …
- Lithium Carbonate + Chlorothiazide— Diuretic-induced sodium loss may reduce lithium clearance and increase serum lithium concentrations.
- Lithium Carbonate + Fluoxetine— Concurrent use has resulted in both increased and decreased serum lithium concentrations; close monitoring required.
- Lithium Carbonate + Furosemide— Diuretic-induced sodium loss may reduce lithium clearance and increase serum lithium concentrations.
- Lithium Carbonate + Hydrochlorothiazide— Diuretic-induced sodium loss may reduce lithium clearance and increase serum lithium concentrations.
- Lithium Carbonate + Ibuprofen— NSAID decreases renal blood flow, resulting in decreased renal clearance and increased serum lithium concentrations.
- Lithium Carbonate + Lisinopril— Renin-angiotensin system antagonist increases steady-state serum lithium concentrations.
- Lithium Carbonate + Naproxen— NSAID decreases renal blood flow, resulting in decreased renal clearance and increased serum lithium concentrations.
- Lithium Carbonate + Nsaid— NSAIDs decrease renal blood flow, resulting in decreased renal clearance and increased serum lithium concentrations. Rec…
- Lithium Carbonate + Nsaids— NSAIDs decrease renal blood flow, resulting in decreased renal clearance and increased serum lithium concentrations. Fre…
- Lithium Carbonate + Potassium Iodide— Concomitant extended use with lithium may produce hypothyroidism.
- Lithium Carbonate + Sodium Bicarbonate— Lowers serum lithium concentrations by increasing urinary lithium excretion; monitor lithium levels.
- Lithium Carbonate + Succinylcholine— May enhance the neuromuscular blocking action of succinylcholine.
- Lithium Carbonate + Urea— Lowers serum lithium concentrations by increasing urinary lithium excretion; monitor lithium levels.
- Lithium Carbonate + Valsartan— Renin-angiotensin system antagonist increases steady-state serum lithium concentrations.
- Lithium Carbonate + Xanthine Derivatives— Concomitant use can lower serum lithium concentrations by increasing urinary lithium excretion. Frequent monitoring and …