Tocainide has 15 known drug interactions based on U.S. FDA drug labeling data. 8 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Lidocaine, Lidocaine 5%, Lidocaine And Prilocaine. Patients taking Tocainide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 15
- Major
- 8
- Moderate
- 7
Major (8)
- Tocainide + Lidocaine— Class I antiarrhythmic; toxic effects are additive and potentially synergistic when used with lidocaine patch 5%.
- Tocainide + Lidocaine 5%— Class I antiarrhythmic; toxic effects are additive and potentially synergistic with lidocaine patch 5%.
- Tocainide + Lidocaine And Prilocaine— Class I antiarrhythmic; toxic effects are additive and potentially synergistic when used with lidocaine and prilocaine c…
- Tocainide + Lidocaine Hydrochloride— Additive and potentially synergistic toxic effects when used concomitantly with lidocaine hydrochloride. Use with cautio…
- Tocainide + Lidocaine Hydrochloride, Menthol— Additive and potentially synergistic toxic effects when used concomitantly with lidocaine hydrochloride and menthol spra…
- Tocainide + Lidocaine, Dimethicone— Lidocaine patch 5% with tocainide has additive and potentially synergistic toxic effects. Use with caution in patients r…
- Tocainide + Lidocaine, Isopropyl Alcohol— Additive and potentially synergistic toxic effects when used concomitantly with lidocaine.
- Tocainide + Lidocaine, Menthol— Concurrent use may result in additive and potentially synergistic toxic effects due to both being Class I antiarrhythmic…
Moderate (7)
- Tocainide + Lidocaine And Capsaicin— Class I antiarrhythmic drug; toxic effects are additive and potentially synergistic when used with lidocaine and capsaic…
- Tocainide + Lidocaine And Tetracaine— Class I antiarrhythmic drug with additive and potentially synergistic systemic toxic effects when used with lidocaine an…
- Tocainide + Lidocaine Hcl, Benzalkonium Chloride— Additive and potentially synergistic toxic effects when used concomitantly with lidocaine HCl/benzalkonium chloride. Use…
- Tocainide + Lidocaine Patch 5%— Toxic effects are additive and potentially synergistic; use with caution in patients receiving Class I antiarrhythmic dr…
- Tocainide + Lidothol Es Patch— Use with caution due to additive and potentially synergistic toxic effects when combined with lidocaine.
- Tocainide + Rifapentine— Rifapentine may increase metabolism and decrease activity. Dosage adjustment may be necessary.
- Tocainide + Trubrexa Patch Er— Toxic effects are additive and potentially synergistic when used concomitantly with Trubrexa Transdermal Patch; use with…