Ergotamine Tartrate has 6 known drug interactions based on U.S. FDA drug labeling data. Of these, 4 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Almotriptan, Almotriptan Malate, Macrolide Antibiotics. Patients taking Ergotamine Tartrate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 6
- Contraindicated
- 4
- Major
- 1
- Moderate
- 1
Contraindicated (4)
- Ergotamine Tartrate + Almotriptan— Do not use within 24 hours of almotriptan due to risk of prolonged vasospastic reactions.
- Ergotamine Tartrate + Almotriptan Malate— Do not use almotriptan malate and ergotamine tartrate within 24 hours of each other due to risk of prolonged vasospastic…
- Ergotamine Tartrate + Macrolide Antibiotics— CYP 3A4 inhibitors that elevate ergotamine blood levels and are associated with vasospastic reactions; contraindicated.
- Ergotamine Tartrate + Protease Inhibitors— CYP 3A4 inhibitors contraindicated with ergotamine tartrate.
Major (1)
- Ergotamine Tartrate + Propranolol— Beta-blocker potentiates the vasoconstrictive action of ergotamine by blocking the vasodilating property of epinephrine.
Moderate (1)
- Ergotamine Tartrate + Nicotine— May provoke vasoconstriction in some patients, predisposing to greater ischemic response to ergot therapy.