Flucytosine has 10 known drug interactions based on U.S. FDA drug labeling data. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Amphotericin B, Cytarabine, Ganciclovir Sodium. Patients taking Flucytosine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 10
- Major
- 5
- Moderate
- 3
Major (5)
- Flucytosine + Amphotericin B— Concurrent use may increase toxicity of flucytosine by increasing cellular uptake and/or impairing renal excretion.
- Flucytosine + Cytarabine— Cytosine arabinoside inactivates the antifungal activity of flucytosine through competitive inhibition.
- Flucytosine + Ganciclovir Sodium— Associated with myelosuppression or nephrotoxicity; coadministration should be considered only if potential benefits out…
- Flucytosine + Valganciclovir— Associated with myelosuppression or nephrotoxicity. Coadministration should be considered only if potential benefits out…
- Flucytosine + Valganciclovir Hydrochloride— Co-administration with valganciclovir should be considered only if potential benefits outweigh risks due to potential fo…
Moderate (3)
- Flucytosine + Amphotericin B Liposome— Concurrent use may increase flucytosine toxicity by possibly increasing cellular uptake and/or impairing renal excretion…
- Flucytosine + Drugs Which Impair Glomerular Filtration— Drugs that impair glomerular filtration may prolong the biological half-life of flucytosine.
- Flucytosine + Ganciclovir— Associated with myelosuppression or nephrotoxicity. Coadministration considered only if benefits outweigh risks.