Alfuzosin Hydrochloride has 7 known drug interactions based on U.S. FDA drug labeling data. Of these, 4 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alfuzosin, Itraconazole, Ketoconazole. Patients taking Alfuzosin Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 7
- Contraindicated
- 4
- Major
- 2
- Moderate
- 1
Contraindicated (4)
- Alfuzosin Hydrochloride + Alfuzosin— 7 DRUG INTERACTIONS Concomitant use of PDE5 inhibitors with alpha adrenergic antagonists, including alfuzosin hydrochlor…
- Alfuzosin Hydrochloride + Itraconazole— 7 DRUG INTERACTIONS Concomitant use of PDE5 inhibitors with alpha adrenergic antagonists, including alfuzosin hydrochlor…
- Alfuzosin Hydrochloride + Ketoconazole— 7 DRUG INTERACTIONS Concomitant use of PDE5 inhibitors with alpha adrenergic antagonists, including alfuzosin hydrochlor…
- Alfuzosin Hydrochloride + Ritonavir— 7 DRUG INTERACTIONS Concomitant use of PDE5 inhibitors with alpha adrenergic antagonists, including alfuzosin hydrochlor…
Major (2)
- Alfuzosin Hydrochloride + Mao Inhibitors— Both classes are vasodilators; concomitant use can potentially cause symptomatic hypotension. Caution is advised.
- Alfuzosin Hydrochloride + Nitrates— Increased risk of hypotension, postural hypotension, and syncope when used concomitantly with alfuzosin.
Moderate (1)
- Alfuzosin Hydrochloride + Alpha-Blockers— Should not be used in combination with alfuzosin. Pharmacokinetic and pharmacodynamic interactions may be expected.