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Levothyroxine And Liothyronine

Also known as: Evexithroid

l-Triiodothyroninel-Thyroxine

Route: Oral

Check Levothyroxine And Liothyronine Interactions →

6 interactions on record⛔ Black Box Warning

Levothyroxine And Liothyronine has 6 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cholestyramine Light, Colestipol, Oral Anticoagulants. Patients taking Levothyroxine And Liothyronine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 6
Major: 3
Moderate: 3

Major (3)

Levothyroxine And Liothyronine + Cholestyramine Light— Cholestyramine binds thyroid hormones in the intestine, impairing their absorption. Space administration by 4-5 hours.
Levothyroxine And Liothyronine + Colestipol— Colestipol binds thyroid hormones in the intestine, impairing their absorption. Space administration by 4-5 hours.
Levothyroxine And Liothyronine + Oral Anticoagulants— Thyroid hormones increase catabolism of vitamin K-dependent clotting factors, impairing compensatory synthesis. Patients…

Moderate (3)

Levothyroxine And Liothyronine + Estrogens— Estrogens increase serum thyroxine-binding globulin, potentially decreasing free levothyroxine. Patients without functio…
Levothyroxine And Liothyronine + Insulin Human— Initiating thyroid replacement therapy may increase insulin requirements. Close monitoring recommended during initiation…
Levothyroxine And Liothyronine + Oral Contraceptives— Estrogen-containing oral contraceptives increase serum thyroxine-binding globulin, potentially decreasing free levothyro…

Levothyroxine And Liothyronine + Cholestyramine Light⚠️Major

Cholestyramine binds thyroid hormones in the intestine, impairing their absorption. Space administration by 4-5 hours.

Levothyroxine And Liothyronine + Colestipol⚠️Major

Colestipol binds thyroid hormones in the intestine, impairing their absorption. Space administration by 4-5 hours.

Levothyroxine And Liothyronine + Oral Anticoagulants⚠️Major

Thyroid hormones increase catabolism of vitamin K-dependent clotting factors, impairing compensatory synthesis. Patients may require reduced anticoagulant dosage when starting thyroid replacement.

Levothyroxine And Liothyronine + Estrogens🟡Moderate

Estrogens increase serum thyroxine-binding globulin, potentially decreasing free levothyroxine. Patients without functioning thyroid gland may require increased thyroid dose.

Levothyroxine And Liothyronine + Insulin Human🟡Moderate

Initiating thyroid replacement therapy may increase insulin requirements. Close monitoring recommended during initiation of thyroid therapy.

Levothyroxine And Liothyronine + Oral Contraceptives🟡Moderate

Estrogen-containing oral contraceptives increase serum thyroxine-binding globulin, potentially decreasing free levothyroxine. Patients without functioning thyroid may require increased thyroid dose.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.