Cholestyramine binds thyroid hormones in the intestine, impairing their absorption. Space administration by 4-5 hours.
Source: NLP:levothyroxine, liothyronine
Levothyroxine And Liothyronine Interactions
Brand names: Evexithroid
l-Triiodothyronine · l-Thyroxine
Route: Oral
FDA Black Box Warning
Drugs with thyroid hormone activity, alone or together with other therapeutic agents, have been used for the treatment of obesity. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects.
Contraindications
CONTRAINDICATIONS Thyroid hormone preparations are generally contraindicated in patients with diagnosed but as yet uncorrected adrenal cortical insufficiency, untreated thyrotoxicosis, and apparent hypersensitivity to any of their active or extraneous constituents. There is no well-documented evidence from the literature, however, of true allergic or idiosyncratic reactions to thyroid hormone.
Pregnancy & Breastfeeding
Pregnancy Thyroid hormones do not readily cross the placental barrier. The clinical experience to date does not indicate any adverse effect on fetuses when thyroid hormones are administered to pregnant women. On the basis of current knowledge, thyroid replacement therapy to hypothyroid women should not be discontinued during pregnancy.
6 interactions on record
Colestipol binds thyroid hormones in the intestine, impairing their absorption. Space administration by 4-5 hours.
Source: NLP:levothyroxine, liothyronine
Thyroid hormones increase catabolism of vitamin K-dependent clotting factors, impairing compensatory synthesis. Patients may require reduced anticoagulant dosage when starting thyroid replacement.
Source: NLP:levothyroxine, liothyronine
Estrogens increase serum thyroxine-binding globulin, potentially decreasing free levothyroxine. Patients without functioning thyroid gland may require increased thyroid dose.
Source: NLP:levothyroxine, liothyronine
Initiating thyroid replacement therapy may increase insulin requirements. Close monitoring recommended during initiation of thyroid therapy.
Source: NLP:levothyroxine, liothyronine
Estrogen-containing oral contraceptives increase serum thyroxine-binding globulin, potentially decreasing free levothyroxine. Patients without functioning thyroid may require increased thyroid dose.
Source: NLP:levothyroxine, liothyronine