Duloxetine Hydrochloride has 12 known drug interactions based on U.S. FDA drug labeling data. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cimetidine, Ciprofloxacin, Enoxacin. Patients taking Duloxetine Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 12
- Major
- 7
- Moderate
- 2
- Minor
- 2
Major (7)
- Duloxetine Hydrochloride + Cimetidine— Potent CYP1A2 inhibitor that should be avoided due to potential significant increase in duloxetine concentrations.
- Duloxetine Hydrochloride + Ciprofloxacin— Quinolone antimicrobial and potent CYP1A2 inhibitor that should be avoided due to potential significant increase in dulo…
- Duloxetine Hydrochloride + Enoxacin— Quinolone antimicrobial and potent CYP1A2 inhibitor that should be avoided due to potential significant increase in dulo…
- Duloxetine Hydrochloride + Fluoxetine— Potent CYP2D6 inhibitor expected to increase duloxetine concentrations similarly to paroxetine.
- Duloxetine Hydrochloride + Fluvoxamine— Potent CYP1A2 inhibitor increases duloxetine AUC approximately 6-fold, Cmax about 2.5-fold, and t1/2 approximately 3-fol…
- Duloxetine Hydrochloride + Paroxetine— Potent CYP2D6 inhibitor that increases duloxetine AUC by about 60%, with greater inhibition expected at higher doses.
- Duloxetine Hydrochloride + Quinidine— Potent CYP2D6 inhibitor expected to increase duloxetine concentrations.
Moderate (2)
- Duloxetine Hydrochloride + Aspirin— Concurrent use may potentiate upper gastrointestinal bleeding risk due to duloxetine's effect on serotonin reuptake.
- Duloxetine Hydrochloride + Warfarin— Potential effect on platelets; patients should be carefully monitored when duloxetine is initiated or discontinued despi…
Minor (2)
- Duloxetine Hydrochloride + Lorazepam— No significant pharmacokinetic interaction with duloxetine under steady-state conditions.
- Duloxetine Hydrochloride + Temazepam— No significant pharmacokinetic interaction with duloxetine under steady-state conditions.