Alfentanil has 14 known drug interactions based on U.S. FDA drug labeling data. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alprazolam, Alprazolam C-Iv, Dexmedetomidine. Patients taking Alfentanil should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 14
- Major
- 6
- Moderate
- 6
- Minor
- 2
Major (6)
- Alfentanil + Alprazolam— Concomitant use increases risk of respiratory depression due to actions at different CNS receptor sites.
- Alfentanil + Alprazolam C-Iv— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Alfentanil + Dexmedetomidine— Concomitant use may cause enhanced CNS depressant effects. Dosage reduction of dexmedetomidine or alfentanil may be requ…
- Alfentanil + Dexmedetomidine Hydrochloride— Enhancement of pharmacodynamic effects. Reduction in dosage of dexmedetomidine or alfentanil may be required. No pharmac…
- Alfentanil + Fluconazole— Fluconazole reduces clearance and distribution volume of alfentanil and prolongs its half-life. Dosage adjustment may be…
- Alfentanil + Itraconazole— Itraconazole increases alfentanil concentrations. Monitor for adverse reactions; concomitant drug dose reduction may be …
Moderate (6)
- Alfentanil + Deferasirox— Deferasirox may induce CYP3A4 resulting in decreased alfentanil concentration. Monitor for reduced effectiveness.
- Alfentanil + Dexmedetomidine Hydrochloride In 0.9% Sodium Chloride— Co-administration leads to enhancement of pharmacodynamic effects. Reduction in dosage of dexmedetomidine or alfentanil …
- Alfentanil + Glycerol Phenylbutyrate— Glycerol phenylbutyrate may decrease systemic exposure. Monitor for decreased efficacy of this narrow therapeutic index …
- Alfentanil + Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate— Methylene blue inhibits CYP3A4/5 metabolism. Alfentanil has narrow therapeutic index; clinical relevance unknown but con…
- Alfentanil + Palbociclib— Sensitive CYP3A substrate with narrow therapeutic index. Dose may need reduction when coadministered with palbociclib.
- Alfentanil + Sevoflurane— Sevoflurane potentiates neuromuscular block when used to supplement alfentanil-N2O anesthesia.
Minor (2)
- Alfentanil + Ondansetron— Ondansetron does not alter the respiratory depressant effects produced by alfentanil.
- Alfentanil + Ondansetron Hydrochloride— Ondansetron does not alter the respiratory depressant effects produced by alfentanil.