Alfentanil Interactions

Concomitant use increases risk of respiratory depression due to actions at different CNS receptor sites.

Source: NLP:alprazolam

Concomitant use may cause enhanced CNS depressant effects. Dosage reduction of dexmedetomidine or alfentanil may be required.

Source: NLP:dexmedetomidine

Fluconazole reduces clearance and distribution volume of alfentanil and prolongs its half-life. Dosage adjustment may be necessary.

Source: NLP:fluconazole

Deferasirox may induce CYP3A4 resulting in decreased alfentanil concentration. Monitor for reduced effectiveness.

Source: NLP:deferasirox

Co-administration with dexmedetomidine hydrochloride leads to enhancement of pharmacodynamic effects. Dosage reduction may be required.

Source: NLP:dexmedetomidine hydrochloride

Glycerol phenylbutyrate may decrease systemic exposure. Monitor for decreased efficacy of this narrow therapeutic index drug.

Source: NLP:glycerol phenylbutyrate

Itraconazole increases alfentanil concentrations. Monitor for adverse reactions; dose reduction may be necessary.

Source: NLP:itraconazole

Sevoflurane potentiates neuromuscular block when used to supplement alfentanil-N2O anesthesia.

Source: NLP:sevoflurane

Ondansetron does not alter the respiratory depressant effects produced by alfentanil.

Source: NLP:ondansetron

Ondansetron does not alter the respiratory depressant effects produced by alfentanil.

Source: NLP:ondansetron hydrochloride