Colistimethate Sodium has 12 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 11 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Sodium Cephalothin, Cisatracurium Besylate, Gallamine. Patients taking Colistimethate Sodium should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 12
- Contraindicated
- 1
- Major
- 11
Contraindicated (1)
- Colistimethate Sodium + Sodium Cephalothin— May enhance nephrotoxicity of colistimethate; concomitant use should be avoided.
Major (11)
- Colistimethate Sodium + Cisatracurium Besylate— May prolong neuromuscular blockade action of cisatracurium besylate. Use peripheral nerve stimulator and monitor clinica…
- Colistimethate Sodium + Gallamine— Potentiates neuromuscular blocking effect and should be used with extreme caution in patients being treated with colisti…
- Colistimethate Sodium + Other Anticholinergic Agents— Potentiates neuromuscular blocking effect and should be used with extreme caution in patients being treated with colisti…
- Colistimethate Sodium + Polymyxins— Polymyxin interferes with nerve transmission at the neuromuscular junction and should not be given concomitantly except …
- Colistimethate Sodium + Pyridostigmine Bromide— Parenteral administration may intensify or produce neuromuscular block and paralysis when used with pyridostigmine.
- Colistimethate Sodium + Rocuronium— May enhance neuromuscular blocking action of rocuronium, prolonging neuromuscular block.
- Colistimethate Sodium + Rocuronium Bromide— May enhance neuromuscular blocking action of rocuronium bromide, causing prolongation of neuromuscular block.
- Colistimethate Sodium + Sodium Citrate— Potentiates neuromuscular blocking effect and should be used with extreme caution in patients being treated with colisti…
- Colistimethate Sodium + Succinylcholine— Potentiates neuromuscular blocking effect and should be used with extreme caution in patients being treated with colisti…
- Colistimethate Sodium + Tubocurarine— Curariform muscle relaxant that potentiates neuromuscular blocking effect; should be used with extreme caution.
- Colistimethate Sodium + Vecuronium Bromide— Sodium colistimethate may intensify or produce neuromuscular block on its own and can cause unexpected prolongation of v…