Colistimethate Sodium + Sodium CephalothinContraindicated
May enhance nephrotoxicity of colistimethate; concomitant use should be avoided.
Source: NLP:colistimethate sodium
Colistimethate Sodium Interactions
Brand names: Colistimethate
Route: Intramuscular, Intravenous
Contraindications
CONTRAINDICATIONS The use of Colistimethate for Injection, USP is contraindicated for patients with a history of sensitivity to the drug or any of its components.
Pregnancy & Breastfeeding
Pregnancy Teratogenic Effects Pregnancy Category C Colistimethate sodium given intramuscularly during organogenesis to rabbits at 4.15 and 9.3 mg/kg resulted in talipes varus in 2.6% and 2.9% of fetuses, respectively. These doses are 0.25 and 0.55 times the maximum daily human dose based on mg/m 2 . In addition, increased resorption occurred at 9.3 mg/kg. Colistimethate sodium was not teratogenic in rats at 4.15 or 9.3 mg/kg. These doses are 0.13 and 0.30 times the maximum daily human dose based on mg/m 2 . There are no adequate and well-controlled studies in pregnant women. Since colistimethate sodium is transferred across the placental barrier in humans, it should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
11 interactions on record
May prolong neuromuscular blockade action of cisatracurium besylate. Use peripheral nerve stimulator and monitor clinical signs.
Source: NLP:cisatracurium besylate
Potentiates neuromuscular blocking effect and should be used with extreme caution in patients being treated with colistimethate.
Source: NLP:colistimethate sodium
Potentiates neuromuscular blocking effect and should be used with extreme caution in patients being treated with colistimethate.
Source: NLP:colistimethate sodium
Polymyxin interferes with nerve transmission at the neuromuscular junction and should not be given concomitantly except with greatest caution.
Source: NLP:colistimethate sodium
May enhance neuromuscular blocking action of rocuronium, prolonging neuromuscular block.
Source: NLP:rocuronium
May enhance neuromuscular blocking action of rocuronium bromide, causing prolongation of neuromuscular block.
Source: NLP:rocuronium bromide
Potentiates neuromuscular blocking effect and should be used with extreme caution in patients being treated with colistimethate.
Source: NLP:colistimethate sodium
Potentiates neuromuscular blocking effect and should be used with extreme caution in patients being treated with colistimethate.
Source: NLP:colistimethate sodium
Curariform muscle relaxant that potentiates neuromuscular blocking effect; should be used with extreme caution.
Source: NLP:colistimethate sodium
Sodium colistimethate may intensify or produce neuromuscular block on its own and can cause unexpected prolongation of vecuronium-induced neuromuscular blockade.
Source: NLP:vecuronium bromide