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Micafungin Sodium

Also known as: Mycamine

Echinocandin Antifungal

Route: Intravenous

12 interactions on record

Micafungin Sodium has 12 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Itraconazole, Nifedipine, Rapamycin. Patients taking Micafungin Sodium should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 12
Moderate: 3
Minor: 9

Moderate (3)

Micafungin Sodium + Itraconazole— 7 DRUG INTERACTIONS Monitor for sirolimus, itraconazole or nifedipine toxicity, and dosage of sirolimus, itraconazole or…
Micafungin Sodium + Nifedipine— 7 DRUG INTERACTIONS Monitor for sirolimus, itraconazole or nifedipine toxicity, and dosage of sirolimus, itraconazole or…
Micafungin Sodium + Rapamycin— Micafungin increases sirolimus AUC by 21%. Monitor for toxicity and reduce sirolimus dosage if necessary.

Minor (9)

Micafungin Sodium + Amphotericin B— Co-administration with micafungin did not alter micafungin pharmacokinetics.
Micafungin Sodium + Cyclosporine— Co-administration with micafungin did not alter cyclosporine pharmacokinetics.
Micafungin Sodium + Fluconazole— Co-administration with micafungin did not alter fluconazole pharmacokinetics.
Micafungin Sodium + Mycophenolate Mofetil— Co-administration with micafungin did not alter pharmacokinetics of either drug.
Micafungin Sodium + Prednisolone— Co-administration with micafungin did not alter pharmacokinetics of either drug.
Micafungin Sodium + Rifampin— Co-administration with micafungin did not alter micafungin pharmacokinetics.
Micafungin Sodium + Ritonavir— Co-administration with micafungin did not alter micafungin pharmacokinetics.
Micafungin Sodium + Tacrolimus— Co-administration with micafungin did not alter pharmacokinetics of either drug.
Micafungin Sodium + Voriconazole— Co-administration with micafungin did not alter voriconazole pharmacokinetics.

Micafungin Sodium + Itraconazole🟡Moderate

7 DRUG INTERACTIONS Monitor for sirolimus, itraconazole or nifedipine toxicity, and dosage of sirolimus, itraconazole or nifedipine should be reduced, if necessary. ( 7 ) 7.1 Effect of Other Drugs on Micafungin CYP3A4, CYP2C9 and CYP2C19 Inhibitors Co-administration of micafungin with cyclosporine, itraconazole, voriconazole and fluconazole did not alter the pharmacokinetics of micafungin. Itraconazole AUC and C max were increased by 22% and 11%, respectively.

Micafungin Sodium + Nifedipine🟡Moderate

7 DRUG INTERACTIONS Monitor for sirolimus, itraconazole or nifedipine toxicity, and dosage of sirolimus, itraconazole or nifedipine should be reduced, if necessary. CYP2C19 and CYP3A4 Inducer Co-administration of micafungin with rifampin and ritonavir did not alter the pharmacokinetics of micafungin Co-administration of Micafungin with Other Drugs Co-administration of micafungin with mycophenolate mofetil (MMF), amphotericin B, tacrolimus, prednisolone, sirolimus and nifedipine did not alter the pharmacokinetics of micafungin. Nifedipine AUC and C max were increased by 18% and 42%, respectively, in the presence of steady-state micafungin compared with nifedipine alone.

Micafungin Sodium + Rapamycin🟡Moderate

Micafungin increases sirolimus AUC by 21%. Monitor for toxicity and reduce sirolimus dosage if necessary.

Micafungin Sodium + Amphotericin B🟢Minor

Co-administration with micafungin did not alter micafungin pharmacokinetics.

Micafungin Sodium + Cyclosporine🟢Minor

Co-administration with micafungin did not alter cyclosporine pharmacokinetics.

Micafungin Sodium + Fluconazole🟢Minor

Co-administration with micafungin did not alter fluconazole pharmacokinetics.

Micafungin Sodium + Mycophenolate Mofetil🟢Minor

Co-administration with micafungin did not alter pharmacokinetics of either drug.

Micafungin Sodium + Prednisolone🟢Minor

Co-administration with micafungin did not alter pharmacokinetics of either drug.

Micafungin Sodium + Rifampin🟢Minor

Co-administration with micafungin did not alter micafungin pharmacokinetics.

Micafungin Sodium + Ritonavir🟢Minor

Co-administration with micafungin did not alter micafungin pharmacokinetics.

Micafungin Sodium + Tacrolimus🟢Minor

Co-administration with micafungin did not alter pharmacokinetics of either drug.

Micafungin Sodium + Voriconazole🟢Minor

Co-administration with micafungin did not alter voriconazole pharmacokinetics.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.