Home›Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine

Also known as: Dexlido Kit

Route: Infiltration, Intramuscular, Intravenous, Topical

Check Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine Interactions →

42 interactions on record⛔ Black Box Warning

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine has 42 known drug interactions based on U.S. FDA drug labeling data. 27 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetaminophen, Acetazolamide, Chloroquine. Patients taking Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 42
Major: 27
Moderate: 15

Major (27)

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Acetaminophen— Associated with increased methemoglobinemia risk when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Acetazolamide— Antibiotics associated with increased methemoglobinemia risk when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Chloroquine— Antimalarial associated with increased methemoglobinemia risk when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Cyclophosphamide— Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitro…
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Dapsone— Antibiotic associated with increased methemoglobinemia risk when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Ergot-Type Oxytocic Drugs— Concurrent administration with Bupivacaine Hydrochloride and Epinephrine may cause severe, persistent hypertension or ce…
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Flutamide— Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitro…
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Fluvoxamine— Strong CYP1A2 inhibitor reduces ropivacaine plasma clearance by 70%, leading to increased ropivacaine levels.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Hydroxyurea— Antineoplastic agent associated with increased methemoglobinemia risk when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Ifosfamide— Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitro…
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Metoclopramide— Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitro…
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Monoamine Oxidase Inhibitors (Maois)— Administration with Bupivacaine Hydrochloride and Epinephrine may produce severe, prolonged hypertension. Concurrent use…
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Nitric Oxide— Increased risk of methemoglobinemia when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Nitrofurantoin— Antibiotic associated with increased methemoglobinemia risk when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Nitroglycerin— Increased risk of methemoglobinemia when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Nitroprusside— Increased risk of methemoglobinemia when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Nitrous Oxide— Increased risk of methemoglobinemia when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Nonselective Beta-Adrenergic Antagonists— Administration with Bupivacaine Hydrochloride and Epinephrine may cause severe hypertension and bradycardia. Concurrent …
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Para-Aminosalicylic Acid— Antibiotic associated with increased methemoglobinemia risk when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Phenobarbital— Anticonvulsant associated with increased methemoglobinemia risk when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Phenytoin— Anticonvulsant associated with increased methemoglobinemia risk when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Primaquine— Antimalarial associated with increased methemoglobinemia risk when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Quinine— Associated with increased methemoglobinemia risk when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Rasburicase— Antineoplastic agent associated with increased methemoglobinemia risk when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Sulfasalazine— Associated with increased methemoglobinemia risk when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Topical Local Anesthetics— Serious dose-related cardiac arrhythmias may occur if preparations containing vasoconstrictor epinephrine are used durin…
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Valproate Sodium— Anticonvulsant associated with increased methemoglobinemia risk when used with ropivacaine.

Moderate (15)

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Amide— Ropivacaine hydrochloride should be used with caution in patients receiving other local anesthetics or agents structural…
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Amiodarone— Caution advised when using class III antiarrhythmic drugs with ropivacaine; specific interaction trials not performed.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Articaine— Additive toxic effects when used with ropivacaine; both are amide-type local anesthetics.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Benzocaine— Additive toxic effects and increased methemoglobinemia risk when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Bupivacaine— Additive toxic effects and increased methemoglobinemia risk when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Butyrophenones— Butyrophenones may reduce or reverse the pressor effect of epinephrine; concurrent use should generally be avoided and r…
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Imipramine— Possible interaction with ropivacaine through CYP1A2 competitive inhibition.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Ketoconazole— CYP3A4 inhibitor causes 15% reduction in ropivacaine plasma clearance.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Lidocaine— Additive toxic effects and increased methemoglobinemia risk when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Mepivacaine— Additive toxic effects when used with ropivacaine; both are amide-type local anesthetics.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Phenothiazines— Phenothiazines may reduce or reverse the pressor effect of epinephrine; concurrent use should generally be avoided and r…
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Prilocaine— Additive toxic effects and increased methemoglobinemia risk when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Procaine— Additive toxic effects when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Tetracaine— Additive toxic effects and increased methemoglobinemia risk when used with ropivacaine.
Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Theophylline— Possible interaction with ropivacaine through CYP1A2 competitive inhibition.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Acetaminophen⚠️Major

Associated with increased methemoglobinemia risk when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Acetazolamide⚠️Major

Antibiotics associated with increased methemoglobinemia risk when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Chloroquine⚠️Major

Antimalarial associated with increased methemoglobinemia risk when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Cyclophosphamide⚠️Major

Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, isofamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine 7.6 Potent Inhalation Anesthetics Serious dose-related cardiac arrhythmias may occur if preparations containing a vasoconstrictor such as epinephrine (e.g., Bupivacaine Hydrochloride and Epinephrine Injection) are used in patients during or following the administration of potent inhalation anesthetics [see Warnings and Precautions (5.13) ] .

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Dapsone⚠️Major

Antibiotic associated with increased methemoglobinemia risk when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Ergot-Type Oxytocic Drugs⚠️Major

Concurrent administration with Bupivacaine Hydrochloride and Epinephrine may cause severe, persistent hypertension or cerebrovascular accidents.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Flutamide⚠️Major

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Fluvoxamine⚠️Major

Strong CYP1A2 inhibitor reduces ropivacaine plasma clearance by 70%, leading to increased ropivacaine levels.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Hydroxyurea⚠️Major

Antineoplastic agent associated with increased methemoglobinemia risk when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Ifosfamide⚠️Major

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Metoclopramide⚠️Major

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Monoamine Oxidase Inhibitors (Maois)⚠️Major

Administration with Bupivacaine Hydrochloride and Epinephrine may produce severe, prolonged hypertension. Concurrent use should generally be avoided.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Nitric Oxide⚠️Major

Increased risk of methemoglobinemia when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Nitrofurantoin⚠️Major

Antibiotic associated with increased methemoglobinemia risk when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Nitroglycerin⚠️Major

Increased risk of methemoglobinemia when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Nitroprusside⚠️Major

Increased risk of methemoglobinemia when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Nitrous Oxide⚠️Major

Increased risk of methemoglobinemia when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Nonselective Beta-Adrenergic Antagonists⚠️Major

Administration with Bupivacaine Hydrochloride and Epinephrine may cause severe hypertension and bradycardia. Concurrent use should generally be avoided.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Para-Aminosalicylic Acid⚠️Major

Antibiotic associated with increased methemoglobinemia risk when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Phenobarbital⚠️Major

Anticonvulsant associated with increased methemoglobinemia risk when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Phenytoin⚠️Major

Anticonvulsant associated with increased methemoglobinemia risk when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Primaquine⚠️Major

Antimalarial associated with increased methemoglobinemia risk when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Quinine⚠️Major

Associated with increased methemoglobinemia risk when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Rasburicase⚠️Major

Antineoplastic agent associated with increased methemoglobinemia risk when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Sulfasalazine⚠️Major

Associated with increased methemoglobinemia risk when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Topical Local Anesthetics⚠️Major

Serious dose-related cardiac arrhythmias may occur if preparations containing vasoconstrictor epinephrine are used during or following potent inhalation anesthetic administration.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Valproate Sodium⚠️Major

Anticonvulsant associated with increased methemoglobinemia risk when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Amide🟡Moderate

Ropivacaine hydrochloride should be used with caution in patients receiving other local anesthetics or agents structurally related to amide-type local anesthetics, since the toxic effects of these drugs are additive. Patients who are administered local anesthetics are at increased risk of developing methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants Phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Amiodarone🟡Moderate

Caution advised when using class III antiarrhythmic drugs with ropivacaine; specific interaction trials not performed.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Articaine🟡Moderate

Additive toxic effects when used with ropivacaine; both are amide-type local anesthetics.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Benzocaine🟡Moderate

Additive toxic effects and increased methemoglobinemia risk when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Bupivacaine🟡Moderate

Additive toxic effects and increased methemoglobinemia risk when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Butyrophenones🟡Moderate

Butyrophenones may reduce or reverse the pressor effect of epinephrine; concurrent use should generally be avoided and requires careful patient monitoring.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Imipramine🟡Moderate

Possible interaction with ropivacaine through CYP1A2 competitive inhibition.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Ketoconazole🟡Moderate

CYP3A4 inhibitor causes 15% reduction in ropivacaine plasma clearance.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Lidocaine🟡Moderate

Additive toxic effects and increased methemoglobinemia risk when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Mepivacaine🟡Moderate

Additive toxic effects when used with ropivacaine; both are amide-type local anesthetics.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Phenothiazines🟡Moderate

Phenothiazines may reduce or reverse the pressor effect of epinephrine; concurrent use should generally be avoided and requires careful patient monitoring.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Prilocaine🟡Moderate

Additive toxic effects and increased methemoglobinemia risk when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Procaine🟡Moderate

Additive toxic effects when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Tetracaine🟡Moderate

Additive toxic effects and increased methemoglobinemia risk when used with ropivacaine.

Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine + Theophylline🟡Moderate

Possible interaction with ropivacaine through CYP1A2 competitive inhibition.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.