Dexmedetomidine has 6 known drug interactions based on U.S. FDA drug labeling data. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alfentanil, Isoflurane, Midazolam. Patients taking Dexmedetomidine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 6
- Major
- 5
- Minor
- 1
Major (5)
- Dexmedetomidine + Alfentanil— Concomitant use may cause enhanced CNS depressant effects. Dosage reduction of dexmedetomidine or alfentanil may be requ…
- Dexmedetomidine + Isoflurane— Concomitant use may cause enhanced CNS depressant effects. Dosage reduction of dexmedetomidine or isoflurane may be requ…
- Dexmedetomidine + Midazolam— Concomitant use may cause enhanced CNS depressant effects. Dosage reduction of dexmedetomidine or midazolam may be requi…
- Dexmedetomidine + Propofol— Concomitant use may cause enhanced CNS depressant effects. Dosage reduction of dexmedetomidine or propofol may be requir…
- Dexmedetomidine + Sevoflurane— Concomitant use may cause enhanced CNS depressant effects. Dosage reduction of dexmedetomidine or sevoflurane may be req…
Minor (1)
- Dexmedetomidine + Rocuronium— Administration of dexmedetomidine resulted in no clinically meaningful increases in neuromuscular blockade magnitude.