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Gorafenib

Kinase InhibitorProtein Kinase Inhibitors

Route: Oral

Check Gorafenib Interactions →
6 interactions on record

Gorafenib has 6 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Neomycin, Rifampin, Ifosfamide. Patients taking Gorafenib should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total
6
Major
2
Moderate
2

Major (2)

  • Gorafenib + Neomycin— Neomycin The concomitant use of sorafenib tablets with neomycin decreased the mean AUC of sorafenib, which may decrease …
  • Gorafenib + Rifampin— Strong CYP3A4 inducer that decreases sorafenib AUC, which may decrease antitumor activity. Avoid concomitant use when po…

Moderate (2)

  • Gorafenib + Ifosfamide— CYP3A4 inhibitor may decrease metabolism of ifosfamide to its active alkylating metabolites, potentially decreasing effe…
  • Gorafenib + Warfarin— May increase risk of bleeding or increased INR. Monitor INR and for clinical bleeding episodes.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.