Halothane has 22 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 13 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Norepinephrine Bitartrate, Adrenalin (Epinephrine), Bupivacaine Hydrochloride And Epinephrine Bitartrate. Patients taking Halothane should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 22
- Contraindicated
- 1
- Major
- 13
- Moderate
- 6
- Minor
- 1
Contraindicated (1)
- Halothane + Norepinephrine Bitartrate— Halothane increases cardiac autonomic irritability and sensitizes the myocardium to norepinephrine, risking ventricular …
Major (13)
- Halothane + Adrenalin (Epinephrine)— Coadministration with halogenated hydrocarbon anesthetics may result in arrhythmias; epinephrine should be administered …
- Halothane + Bupivacaine Hydrochloride And Epinephrine Bitartrate— Serious dose-related cardiac arrhythmias may occur when epinephrine-containing preparations are used during or following…
- Halothane + Dexmethylphenidate Hydrochloride— Concomitant use may increase risk of sudden blood pressure and heart rate increase during surgery. Avoid use on day of s…
- Halothane + Epinephrine— Halogenated hydrocarbon anesthetic that potentiates arrhythmogenic effects of epinephrine.
- Halothane + Epinephrine In Sodium Chloride— Halogenated hydrocarbon anesthetic that increases arrhythmogenic potential of epinephrine.
- Halothane + Isoproterenol Hydrochloride— Avoid concurrent use due to potential to sensitize myocardium to sympathomimetic amine effects, increasing arrhythmia ri…
- Halothane + Labetalol— Synergism between halothane anesthesia and intravenous labetalol increases hypotension and risks of reduced cardiac outp…
- Halothane + Labetalol Hydrochloride— Synergism shown between halothane and intravenous labetalol; high concentrations (≥3%) may increase hypotension, reduce …
- Halothane + Methylphenidate Hydrochloride— Concomitant use may increase risk of sudden blood pressure and heart rate increase during surgery. Avoid use on day of s…
- Halothane + Methylphenidate Hydrochloride Extended Release— Concomitant use may increase risk of sudden blood pressure and heart rate increase during surgery. Avoid on day of surge…
- Halothane + Propofol— Increases anesthetic/sedative and cardiorespiratory effects of propofol during maintenance anesthesia. Concurrent use is…
- Halothane + Rifampin— Concomitant use increases potential for hepatotoxicity. Concomitant use should be avoided.
- Halothane + Vecuronium Bromide— Halothane enhances vecuronium-induced neuromuscular blockade when used concurrently.
Moderate (6)
- Halothane + Atracurium Besylate— May enhance the neuromuscular blocking action of atracurium.
- Halothane + Fosphenytoin Sodium— May increase plasma phenytoin concentrations after fosphenytoin conversion.
- Halothane + Methohexital Sodium— Methohexital may influence the metabolism of halothane.
- Halothane + Methylergonovine— Anesthetic that may reduce the oxytocic potency of methylergonovine.
- Halothane + Methylergonovine Maleate— Anesthetic that may reduce the oxytocic potency of methylergonovine maleate.
- Halothane + Propofol Injectable Emulsion— Concurrent administration during maintenance can increase anesthetic/sedative and cardiorespiratory effects of propofol.
Minor (1)
- Halothane + Rocuronium Bromide— No definite interaction with rocuronium bromide has been demonstrated; does not affect median spontaneous recovery time.