Quetiapine has 14 known drug interactions based on U.S. FDA drug labeling data. 10 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alcohol, Carbamazepine, Indinavir. Patients taking Quetiapine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 14
- Major
- 10
- Moderate
- 4
Major (10)
- Quetiapine + Alcohol— Potentiates cognitive and motor effects of quetiapine. Alcoholic beverages should be limited while taking quetiapine.
- Quetiapine + Carbamazepine— CYP3A4 inducer decreases quetiapine exposure; dose adjustment of quetiapine necessary.
- Quetiapine + Indinavir— CYP3A4 inhibitor increases quetiapine exposure; dose reduction of quetiapine necessary.
- Quetiapine + Itraconazole— CYP3A4 inhibitor increases quetiapine exposure; dose reduction of quetiapine necessary.
- Quetiapine + Ketoconazole— Strong CYP3A4 inhibitor significantly increases quetiapine exposure; reduce quetiapine dose to one sixth of original dos…
- Quetiapine + Nefazodone— CYP3A4 inhibitor increases quetiapine exposure; dose reduction of quetiapine necessary.
- Quetiapine + Phenytoin— Potent CYP3A4 inducer increases quetiapine clearance 5-fold; increase quetiapine dose up to 5-fold during chronic use an…
- Quetiapine + Rifampin— Potent CYP3A4 inducer increases quetiapine clearance; increase quetiapine dose up to 5-fold during chronic use and reduc…
- Quetiapine + Ritonavir— Strong CYP3A4 inhibitor significantly increases quetiapine exposure; reduce quetiapine dose to one sixth of original dos…
- Quetiapine + St. John'S Wort— Potent CYP3A4 inducer increases quetiapine clearance; increase quetiapine dose up to 5-fold during chronic use and reduc…
Moderate (4)
- Quetiapine + Acidifying Agents— Quetiapine may enhance the effects of antihypertensive agents due to its hypotensive potential.
- Quetiapine + Deferasirox— Deferasirox may induce CYP3A4 resulting in decreased quetiapine concentration. Monitor for reduced effectiveness.
- Quetiapine + Dopamine Agonists— Quetiapine may antagonize the effects of dopamine agonists. Caution advised with concomitant use.
- Quetiapine + Levodopa— Quetiapine may antagonize the effects of levodopa. Caution advised with concomitant use.