Life-threatening interactions with MAO inhibitors; serotonin syndrome reported.
Source: NLP:cyclobenzaprine hydrochloride
Brand names: Cyclobenzaprine Hydrochloride
Route: Oral
Contraindications
CONTRAINDICATIONS Hypersensitivity to any component of this product. Concomitant use of monoamine oxidase (MAO) inhibitors or within 14 days after their discontinuation. Hyperpyretic crisis seizures, and deaths have occurred in patients receiving cyclobenzaprine (or structurally similar tricyclic antidepressants) concomitantly with MAO inhibitor drugs. Acute recovery phase of myocardial infarction, and patients with arrhythmias, heart block or conduction disturbances, or congestive heart failure. Hyperthyroidism.
Pregnancy & Breastfeeding
Pregnancy: Pregnancy Category B Reproduction studies have been performed in rats, mice and rabbits at doses up to 20 times the human dose, and have revealed no evidence of impaired fertility or harm to the fetus due to cyclobenzaprine hydrochloride. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
10 interactions on record
Life-threatening interactions with MAO inhibitors; serotonin syndrome reported.
Source: NLP:cyclobenzaprine hydrochloride
Postmarketing cases of serotonin syndrome reported during combined use.
Source: NLP:cyclobenzaprine hydrochloride
Serotonin syndrome reported during combined use.
Source: NLP:cyclobenzaprine hydrochloride
Postmarketing cases of serotonin syndrome reported during combined use. Careful observation advised, particularly during treatment initiation or dose increases.
Source: NLP:cyclobenzaprine hydrochloride
Serotonin syndrome reported; may enhance seizure risk when combined with tramadol.
Source: NLP:cyclobenzaprine hydrochloride
Serotonin syndrome reported; seizure risk may be enhanced.
Source: NLP:cyclobenzaprine hydrochloride
Serotonin syndrome reported during combined use.
Source: NLP:cyclobenzaprine hydrochloride
Cyclobenzaprine may enhance CNS depressant effects of alcohol.
Source: NLP:cyclobenzaprine hydrochloride
Cyclobenzaprine may enhance CNS depressant effects of barbiturates.
Source: NLP:cyclobenzaprine hydrochloride
Tricyclic antidepressants may block the antihypertensive action of guanethidine.
Source: NLP:cyclobenzaprine hydrochloride