Cyclobenzaprine Hydrochloride has 10 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 8 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Mao Inhibitors, Alcohol, Barbiturates. Patients taking Cyclobenzaprine Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 10
- Contraindicated
- 1
- Major
- 8
- Moderate
- 1
Contraindicated (1)
- Cyclobenzaprine Hydrochloride + Mao Inhibitors— Life-threatening interactions with MAO inhibitors; serotonin syndrome reported.
Major (8)
- Cyclobenzaprine Hydrochloride + Alcohol— Cyclobenzaprine may enhance the effects of alcohol and other CNS depressants.
- Cyclobenzaprine Hydrochloride + Barbiturates— Cyclobenzaprine may enhance the effects of barbiturates and other CNS depressants.
- Cyclobenzaprine Hydrochloride + Bupropion— Postmarketing cases of serotonin syndrome reported during combined use.
- Cyclobenzaprine Hydrochloride + Meperidine— Serotonin syndrome reported during combined use.
- Cyclobenzaprine Hydrochloride + Selective Serotonin Reuptake Inhibitors (Ssri)— Postmarketing cases of serotonin syndrome reported during combined use. Careful observation advised, particularly during…
- Cyclobenzaprine Hydrochloride + Tcas— Serotonin syndrome reported; may enhance seizure risk when combined with tramadol.
- Cyclobenzaprine Hydrochloride + Tramadol— Serotonin syndrome reported; seizure risk may be enhanced.
- Cyclobenzaprine Hydrochloride + Verapamil— Serotonin syndrome reported during combined use.
Moderate (1)
- Cyclobenzaprine Hydrochloride + Guanethidine— Tricyclic antidepressants may block the antihypertensive action of guanethidine.