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Heparin

44 interactions on record

Heparin has 44 known drug interactions based on U.S. FDA drug labeling data. Of these, 5 are contraindicated combinations that should be avoided entirely. 30 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with (Sotradecol) Sodium Tetradecyl Sulfate, Andexanet Alfa, Defibrotide Sodium. Patients taking Heparin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 44
Contraindicated: 5
Major: 30
Moderate: 9

Contraindicated (5)

Heparin + (Sotradecol) Sodium Tetradecyl Sulfate— Heparin should not be included in the same syringe as Sotradecol due to incompatibility.
Heparin + Andexanet Alfa— Unresponsiveness to unfractionated heparin following ANDEXANET ALFA administration, characterized by non-prolongation of…
Heparin + Defibrotide Sodium— DEFITELIO may enhance the pharmacodynamic activity of heparin, increasing risk of hemorrhage. Concomitant use is contrai…
Heparin + Sodium Tetradecyl Sulfate— Heparin should not be included in the same syringe as Sotradecol due to incompatibility.
Heparin + Tetradecyl Hydrogen Sulfate (Ester)— Heparin should not be included in the same syringe as Sotradecol due to incompatibility.

Major (30)

Heparin + Apixaban— Anticoagulant that increases bleeding risk when coadministered with apixaban.
Heparin + Aspirin And Dipyridamole— Aspirin increases the anticoagulant activity of heparin, increasing bleeding risk.
Heparin + Aspirin And Extended - Release Dipyridamole— Aspirin increases the anticoagulant activity of heparin, increasing bleeding risk.
Heparin + Asprin And Extended-Release Dipyridamole— Aspirin increases anticoagulant activity of heparin, increasing bleeding risk.
Heparin + Bivalirudin— Co-administration with bivalirudin associated with increased risk of major bleeding events in patients undergoing PCI/PT…
Heparin + Caplacizumab— Concomitant use may increase the risk of bleeding. Avoid concomitant use when possible and monitor closely for bleeding.
Heparin + Carospir— Heparin may increase serum potassium, leading to severe hyperkalemia when used with CAROSPIR.
Heparin + Eptifibatide— Coadministration increases the risk of bleeding.
Heparin + Ferrous Fumarate, Folate— Pyridoxine interaction with Heparin may increase bleeding risk.
Heparin + Ferrous Fumarate, Folic Acid— Possibility of increased bleeding due to pyridoxine interaction with anticoagulants.
Heparin + Folate, Multivitamin— Possibility of increased bleeding due to pyridoxine interaction with anticoagulants.
Heparin + Folic Acid— Possibility of increased bleeding due to folic acid interaction with anticoagulants.
Heparin + Indocyanine Green— Heparin products containing sodium bisulfite reduce the absorption peak of Indocyanine Green in blood and should not be …
Heparin + Ketorolac Tromethamine— Administration should be done extremely cautiously with close monitoring due to potential increased bleeding risk, altho…
Heparin + Multivitamin— Pyridoxine in the multivitamin may increase bleeding risk when used with anticoagulants.
Heparin + Nitroglycerin— Intravenous nitroglycerin interferes with the anticoagulant effect of heparin in some patients. Concomitant heparin ther…
Heparin + Olmesartan Medoxomil— May increase potassium levels and lead to increases in serum potassium. Monitoring of serum potassium is advisable.
Heparin + Oxycodone And Aspirin— Aspirin increases anticoagulant activity of heparin, significantly increasing bleeding risk.
Heparin + Paroxetine— Concurrent use of heparin with paroxetine may potentiate the risk of bleeding.
Heparin + Paroxetine Hydrochloride— Increased bleeding risk when combined with paroxetine. Inform patients of increased bleeding risk.
Heparin + Paroxetine Hydrochloride Hemihydrate— Increased risk of bleeding with concurrent anticoagulant use; inform patients of increased bleeding risk.
Heparin + Perindopril Erbumine— Risk of hyperkalemia. Heparin is capable of increasing serum potassium.
Heparin + Salicylic Acid— Salicylate decreases platelet adhesiveness and interferes with hemostasis in heparin-treated patients.
Heparin + Salicylic Acid 10%— Salicylate decreases platelet adhesiveness and interferes with hemostasis in heparin-treated patients.
Heparin + Sertraline— Concurrent use may potentiate bleeding risk. Inform patients of increased bleeding risk.
Heparin + Sertraline Hydrochloride— Concurrent use may potentiate risk of bleeding.
Heparin + Spironolactone— Heparin can increase serum potassium; concomitant use with spironolactone may lead to severe hyperkalemia.
Heparin + Spironolactone And Hydrochlorothiazide— Concomitant administration may lead to severe hyperkalemia.
Heparin + Valsartan— May increase serum potassium levels leading to hyperkalemia, particularly in heart failure patients with increased serum…
Heparin + Valsartan And Hydrochlorothiazide— May increase serum potassium levels when used concomitantly with valsartan, potentially leading to increased serum creat…

Moderate (9)

Heparin + Alprostadil— Concomitant administration with alprostadil causes significant increases in partial thromboplastin time (140%) and throm…
Heparin + Amlodipine And Valsartan— May increase serum potassium levels when combined with valsartan. Monitor serum potassium levels.
Heparin + Argatroban— Allow sufficient time for heparin's effect on aPTT to decrease before initiating argatroban therapy to avoid excessive a…
Heparin + Drospirenone— May increase serum potassium concentration when used with drospirenone.
Heparin + Levothyroxine Sodium— May alter serum T4 and T3 transport affecting levothyroxine efficacy.
Heparin + Liothyronine Sodium— May cause protein binding site displacement of thyroid hormones. Closely monitor thyroid hormone parameters.
Heparin + Palifermin— Palifermin interacts with unfractionated heparin; heparin increases systemic exposure of palifermin. Rinse IV line with …
Heparin + Piperacillin And Tazobactam— Monitor coagulation parameters in patients receiving piperacillin and tazobactam with heparin.
Heparin + Potassium Bicarbonate— May produce unfavorable interactions with potassium supplements, risk of hyperkalemia.

Heparin + (Sotradecol) Sodium Tetradecyl Sulfate⛔Contraindicated

Heparin should not be included in the same syringe as Sotradecol due to incompatibility.

Heparin + Andexanet Alfa⛔Contraindicated

Unresponsiveness to unfractionated heparin following ANDEXANET ALFA administration, characterized by non-prolongation of activated clotting times and requirement for increased heparin dosing. Do not use unfractionated heparin following ANDEXANET ALFA administration.

Heparin + Defibrotide Sodium⛔Contraindicated

DEFITELIO may enhance the pharmacodynamic activity of heparin, increasing risk of hemorrhage. Concomitant use is contraindicated.

Heparin + Sodium Tetradecyl Sulfate⛔Contraindicated

Heparin should not be included in the same syringe as Sotradecol due to incompatibility.

Heparin + Tetradecyl Hydrogen Sulfate (Ester)⛔Contraindicated

Heparin should not be included in the same syringe as Sotradecol due to incompatibility.

Heparin + Apixaban⚠️Major

Anticoagulant that increases bleeding risk when coadministered with apixaban.

Heparin + Aspirin And Dipyridamole⚠️Major

Aspirin increases the anticoagulant activity of heparin, increasing bleeding risk.

Heparin + Aspirin And Extended - Release Dipyridamole⚠️Major

Aspirin increases the anticoagulant activity of heparin, increasing bleeding risk.

Heparin + Asprin And Extended-Release Dipyridamole⚠️Major

Aspirin increases anticoagulant activity of heparin, increasing bleeding risk.

Heparin + Bivalirudin⚠️Major

Co-administration with bivalirudin associated with increased risk of major bleeding events in patients undergoing PCI/PTCA.

Heparin + Caplacizumab⚠️Major

Concomitant use may increase the risk of bleeding. Avoid concomitant use when possible and monitor closely for bleeding.

Heparin + Carospir⚠️Major

Heparin may increase serum potassium, leading to severe hyperkalemia when used with CAROSPIR.

Heparin + Eptifibatide⚠️Major

Coadministration increases the risk of bleeding.

Heparin + Ferrous Fumarate, Folate⚠️Major

Pyridoxine interaction with Heparin may increase bleeding risk.

Heparin + Ferrous Fumarate, Folic Acid⚠️Major

Possibility of increased bleeding due to pyridoxine interaction with anticoagulants.

Heparin + Folate, Multivitamin⚠️Major

Possibility of increased bleeding due to pyridoxine interaction with anticoagulants.

Heparin + Folic Acid⚠️Major

Possibility of increased bleeding due to folic acid interaction with anticoagulants.

Heparin + Indocyanine Green⚠️Major

Heparin products containing sodium bisulfite reduce the absorption peak of Indocyanine Green in blood and should not be used as an anticoagulant for sample collection.

Heparin + Ketorolac Tromethamine⚠️Major

Administration should be done extremely cautiously with close monitoring due to potential increased bleeding risk, although in vitro studies showed minimal effect on template bleeding time.

Heparin + Multivitamin⚠️Major

Pyridoxine in the multivitamin may increase bleeding risk when used with anticoagulants.

Heparin + Nitroglycerin⚠️Major

Intravenous nitroglycerin interferes with the anticoagulant effect of heparin in some patients. Concomitant heparin therapy should be guided by frequent measurement of activated partial thromboplastin time.

Heparin + Olmesartan Medoxomil⚠️Major

May increase potassium levels and lead to increases in serum potassium. Monitoring of serum potassium is advisable.

Heparin + Oxycodone And Aspirin⚠️Major

Aspirin increases anticoagulant activity of heparin, significantly increasing bleeding risk.

Heparin + Paroxetine⚠️Major

Concurrent use of heparin with paroxetine may potentiate the risk of bleeding.

Heparin + Paroxetine Hydrochloride⚠️Major

Increased bleeding risk when combined with paroxetine. Inform patients of increased bleeding risk.

Heparin + Paroxetine Hydrochloride Hemihydrate⚠️Major

Increased risk of bleeding with concurrent anticoagulant use; inform patients of increased bleeding risk.

Heparin + Perindopril Erbumine⚠️Major

Risk of hyperkalemia. Heparin is capable of increasing serum potassium.

Heparin + Salicylic Acid⚠️Major

Salicylate decreases platelet adhesiveness and interferes with hemostasis in heparin-treated patients.

Heparin + Salicylic Acid 10%⚠️Major

Salicylate decreases platelet adhesiveness and interferes with hemostasis in heparin-treated patients.

Heparin + Sertraline⚠️Major

Concurrent use may potentiate bleeding risk. Inform patients of increased bleeding risk.

Heparin + Sertraline Hydrochloride⚠️Major

Concurrent use may potentiate risk of bleeding.

Heparin + Spironolactone⚠️Major

Heparin can increase serum potassium; concomitant use with spironolactone may lead to severe hyperkalemia.

Heparin + Spironolactone And Hydrochlorothiazide⚠️Major

Concomitant administration may lead to severe hyperkalemia.

Heparin + Valsartan⚠️Major

May increase serum potassium levels leading to hyperkalemia, particularly in heart failure patients with increased serum creatinine.

Heparin + Valsartan And Hydrochlorothiazide⚠️Major

May increase serum potassium levels when used concomitantly with valsartan, potentially leading to increased serum creatinine in heart failure patients.

Heparin + Alprostadil🟡Moderate

Concomitant administration with alprostadil causes significant increases in partial thromboplastin time (140%) and thrombin time (120%). Caution should be exercised.

Heparin + Amlodipine And Valsartan🟡Moderate

May increase serum potassium levels when combined with valsartan. Monitor serum potassium levels.

Heparin + Argatroban🟡Moderate

Allow sufficient time for heparin's effect on aPTT to decrease before initiating argatroban therapy to avoid excessive anticoagulation.

Heparin + Drospirenone🟡Moderate

May increase serum potassium concentration when used with drospirenone.

Heparin + Levothyroxine Sodium🟡Moderate

May alter serum T4 and T3 transport affecting levothyroxine efficacy.

Heparin + Liothyronine Sodium🟡Moderate

May cause protein binding site displacement of thyroid hormones. Closely monitor thyroid hormone parameters.

Heparin + Palifermin🟡Moderate

Palifermin interacts with unfractionated heparin; heparin increases systemic exposure of palifermin. Rinse IV line with saline before and after palifermin administration.

Heparin + Piperacillin And Tazobactam🟡Moderate

Monitor coagulation parameters in patients receiving piperacillin and tazobactam with heparin.

Heparin + Potassium Bicarbonate🟡Moderate

May produce unfavorable interactions with potassium supplements, risk of hyperkalemia.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.