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Hyaluronidase

Also known as: Hylenex Recombinant

Endoglycosidase

Route: Subcutaneous

12 interactions on record

Hyaluronidase has 12 known drug interactions based on U.S. FDA drug labeling data. Of these, 5 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alpha-Blockers, Dopamine Agonists, Furosemide. Patients taking Hyaluronidase should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 12
Contraindicated: 5
Major: 1
Moderate: 6

Contraindicated (5)

Hyaluronidase + Alpha-Blockers— Hyaluronidase should not be used to enhance the dispersion and absorption of alpha agonist drugs.
Hyaluronidase + Dopamine Agonists— Hyaluronidase should not be used to enhance the dispersion and absorption of dopamine.
Hyaluronidase + Furosemide— Furosemide is incompatible with hyaluronidase.
Hyaluronidase + Nitrazepam— Benzodiazepines are incompatible with hyaluronidase.
Hyaluronidase + Phenytoin— Phenytoin is incompatible with hyaluronidase.

Major (1)

Hyaluronidase + Topical Local Anesthetics— Hyaluronidase hastens onset and shortens duration of effect of local anesthetics, increasing incidence of systemic react…

Moderate (6)

Hyaluronidase + Antihistamines— Large doses of antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs …
Hyaluronidase + Cortisone— Large doses of cortisone may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs rende…
Hyaluronidase + Estrogens— Large doses of estrogens may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs rende…
Hyaluronidase + Lidocaine With Epinephrine— 2% lidocaine with 1:100,000 or 1:200,000 epinephrine is incompatible with hyaluronidase due to sodium metabisulfite pres…
Hyaluronidase + Repository Corticotropin— Large doses of ACTH may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs render tis…
Hyaluronidase + Salicylates— Large doses of salicylates may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs ren…

Hyaluronidase + Alpha-Blockers⛔Contraindicated

Hyaluronidase should not be used to enhance the dispersion and absorption of alpha agonist drugs.

Hyaluronidase + Dopamine Agonists⛔Contraindicated

Hyaluronidase should not be used to enhance the dispersion and absorption of dopamine.

Hyaluronidase + Furosemide⛔Contraindicated

Furosemide is incompatible with hyaluronidase.

Hyaluronidase + Nitrazepam⛔Contraindicated

Benzodiazepines are incompatible with hyaluronidase.

Hyaluronidase + Phenytoin⛔Contraindicated

Phenytoin is incompatible with hyaluronidase.

Hyaluronidase + Topical Local Anesthetics⚠️Major

Hyaluronidase hastens onset and shortens duration of effect of local anesthetics, increasing incidence of systemic reactions due to wider spread and increased absorption.

Hyaluronidase + Antihistamines🟡Moderate

Large doses of antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs render tissues partly resistant to hyaluronidase action.

Hyaluronidase + Cortisone🟡Moderate

Large doses of cortisone may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs render tissues partly resistant to hyaluronidase action.

Hyaluronidase + Estrogens🟡Moderate

Large doses of estrogens may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs render tissues partly resistant to hyaluronidase action.

Hyaluronidase + Lidocaine With Epinephrine🟡Moderate

2% lidocaine with 1:100,000 or 1:200,000 epinephrine is incompatible with hyaluronidase due to sodium metabisulfite present in anesthetic formulation.

Hyaluronidase + Repository Corticotropin🟡Moderate

Large doses of ACTH may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs render tissues partly resistant to hyaluronidase action.

Hyaluronidase + Salicylates🟡Moderate

Large doses of salicylates may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs render tissues partly resistant to hyaluronidase action.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.