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Hyaluronidase

Also known as: Hylenex Recombinant

Endoglycosidase

Route: Subcutaneous

12 interactions on record

Hyaluronidase has 12 known drug interactions based on U.S. FDA drug labeling data. Of these, 5 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alpha-Blockers, Dopamine Agonists, Furosemide. Patients taking Hyaluronidase should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 12
Contraindicated: 5
Major: 1
Moderate: 6

Contraindicated (5)

Hyaluronidase + Alpha-Blockers— Hyaluronidase should not be used to enhance the dispersion and absorption of alpha agonist drugs.
Hyaluronidase + Dopamine Agonists— Hyaluronidase should not be used to enhance the dispersion and absorption of dopamine.
Hyaluronidase + Furosemide— Furosemide is incompatible with hyaluronidase.
Hyaluronidase + Nitrazepam— Benzodiazepines are incompatible with hyaluronidase.
Hyaluronidase + Phenytoin— Phenytoin is incompatible with hyaluronidase.

Major (1)

Hyaluronidase + Topical Local Anesthetics— Hyaluronidase hastens onset and shortens duration of effect of local anesthetics, increasing incidence of systemic react…

Moderate (6)

Hyaluronidase + Antihistamines— Large doses of antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs …
Hyaluronidase + Cortisone— Large doses of cortisone may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs rende…
Hyaluronidase + Estrogens— Large doses of estrogens may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs rende…
Hyaluronidase + Lidocaine With Epinephrine— 2% lidocaine with 1:100,000 or 1:200,000 epinephrine is incompatible with hyaluronidase due to sodium metabisulfite pres…
Hyaluronidase + Repository Corticotropin— Large doses of ACTH may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs render tis…
Hyaluronidase + Salicylates— Large doses of salicylates may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs ren…

Hyaluronidase + Alpha-Blockers⛔Contraindicated

Hyaluronidase should not be used to enhance the dispersion and absorption of alpha agonist drugs.

Hyaluronidase + Dopamine Agonists⛔Contraindicated

Hyaluronidase should not be used to enhance the dispersion and absorption of dopamine.

Hyaluronidase + Furosemide⛔Contraindicated

Furosemide is incompatible with hyaluronidase.

Hyaluronidase + Nitrazepam⛔Contraindicated

Benzodiazepines are incompatible with hyaluronidase.

Hyaluronidase + Phenytoin⛔Contraindicated

Phenytoin is incompatible with hyaluronidase.

Hyaluronidase + Topical Local Anesthetics⚠️Major

Hyaluronidase hastens onset and shortens duration of effect of local anesthetics, increasing incidence of systemic reactions due to wider spread and increased absorption.

Hyaluronidase + Antihistamines🟡Moderate

Large doses of antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs render tissues partly resistant to hyaluronidase action.

Hyaluronidase + Cortisone🟡Moderate

Large doses of cortisone may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs render tissues partly resistant to hyaluronidase action.

Hyaluronidase + Estrogens🟡Moderate

Large doses of estrogens may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs render tissues partly resistant to hyaluronidase action.

Hyaluronidase + Lidocaine With Epinephrine🟡Moderate

2% lidocaine with 1:100,000 or 1:200,000 epinephrine is incompatible with hyaluronidase due to sodium metabisulfite present in anesthetic formulation.

Hyaluronidase + Repository Corticotropin🟡Moderate

Large doses of ACTH may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs render tissues partly resistant to hyaluronidase action.

Hyaluronidase + Salicylates🟡Moderate

Large doses of salicylates may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs render tissues partly resistant to hyaluronidase action.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.