Hydrocortisone has 25 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cyclosporine, Phenylephrine Hydrochloride, Acetylsalicylic Acid. Patients taking Hydrocortisone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 25
- Major
- 2
- Moderate
- 23
Major (2)
- Hydrocortisone + Cyclosporine— Increased activity of both drugs; convulsions reported with concurrent use. Monitor patients receiving both agents.
- Hydrocortisone + Phenylephrine Hydrochloride— Agonistic effects increase phenylephrine blood pressure effect.
Moderate (23)
- Hydrocortisone + Acetylsalicylic Acid— Corticosteroids may increase aspirin clearance, leading to decreased salicylate levels or increased toxicity upon cortic…
- Hydrocortisone + Carbamazepine— CYP3A4 inducer may decrease serum hydrocortisone concentrations and increase risk of adrenal crisis; may require dose in…
- Hydrocortisone + Clarithromycin— CYP3A4 inhibitor may increase serum hydrocortisone concentrations and risk of adverse reactions; may require dose decrea…
- Hydrocortisone + Colestipol Hydrochloride— Bile acid binding resins may interfere with the absorption of hydrocortisone.
- Hydrocortisone + Efavirenz— CYP3A4 inducer may decrease serum hydrocortisone concentrations and increase risk of adrenal crisis; may require dose in…
- Hydrocortisone + Erythromycin— CYP3A4 inhibitor may increase serum hydrocortisone concentrations and risk of adverse reactions; may require dose decrea…
- Hydrocortisone + Estrogens— May increase serum cortisol-binding globulin, reducing hydrocortisone efficacy; may require dose increase.
- Hydrocortisone + Grapefruit Juice— CYP3A4 inhibitor may increase serum hydrocortisone concentrations and risk of adverse reactions; may require dose decrea…
- Hydrocortisone + Itraconazole— CYP3A4 inhibitor may increase serum hydrocortisone concentrations and risk of adverse reactions; may require dose decrea…
- Hydrocortisone + Ketoconazole— Inhibits metabolism of corticosteroids and decreases their clearance, requiring dose titration to avoid steroid toxicity…
- Hydrocortisone + Nevirapine— CYP3A4 inducer may decrease serum hydrocortisone concentrations and increase risk of adrenal crisis; may require dose in…
- Hydrocortisone + Oral Anticoagulants— Variable effect with reports of both enhanced and diminished anticoagulant effects when given concurrently with corticos…
- Hydrocortisone + Oxcarbazepine— CYP3A4 inducer may decrease serum hydrocortisone concentrations and increase risk of adrenal crisis; may require dose in…
- Hydrocortisone + Phenobarbital— Induces hepatic enzymes and increases clearance of corticosteroids, may require increased corticosteroid dose to achieve…
- Hydrocortisone + Phenytoin— Induces hepatic enzymes and increases clearance of corticosteroids, may require increased corticosteroid dose to achieve…
- Hydrocortisone + Posaconazole— CYP3A4 inhibitor may increase serum hydrocortisone concentrations and risk of adverse reactions; may require dose decrea…
- Hydrocortisone + Primidone— CYP3A4 inducer may decrease serum hydrocortisone concentrations and increase risk of adrenal crisis; may require dose in…
- Hydrocortisone + Rifabutin— CYP3A4 inducer may decrease serum hydrocortisone concentrations and increase risk of adrenal crisis; may require dose in…
- Hydrocortisone + Rifampin— Induces hepatic enzymes and increases clearance of corticosteroids, may require increased corticosteroid dose to achieve…
- Hydrocortisone + Ritonavir— CYP3A4 inhibitor may increase serum hydrocortisone concentrations and risk of adverse reactions; may require dose decrea…
- Hydrocortisone + Troleandomycin— Inhibits metabolism of corticosteroids and decreases their clearance, requiring dose titration to avoid steroid toxicity…
- Hydrocortisone + Voriconazole— CYP3A4 inhibitor may increase serum hydrocortisone concentrations and risk of adverse reactions; may require dose decrea…
- Hydrocortisone + Warfarin— Corticosteroids usually inhibit warfarin response; monitor coagulation indices to maintain anticoagulant effect.