Hydrocortisone has 25 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cyclosporine, Phenylephrine Hydrochloride, Aspirin. Patients taking Hydrocortisone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 25
- Major
- 2
- Moderate
- 23
Major (2)
- Hydrocortisone + Cyclosporine— Increased activity of both drugs; convulsions reported with concurrent use. Monitor patients receiving both agents.
- Hydrocortisone + Phenylephrine Hydrochloride— Agonistic effects increase phenylephrine blood pressure effect.
Moderate (23)
- Hydrocortisone + Aspirin— Corticosteroids may increase aspirin clearance, leading to decreased salicylate levels or increased toxicity upon cortic…
- Hydrocortisone + Carbamazepine— CYP3A4 inducer may decrease serum hydrocortisone concentrations and increase risk of adrenal crisis; may require dose in…
- Hydrocortisone + Clarithromycin— CYP3A4 inhibitor may increase serum hydrocortisone concentrations and risk of adverse reactions; may require dose decrea…
- Hydrocortisone + Colestipol Hydrochloride— Bile acid binding resins may interfere with the absorption of hydrocortisone.
- Hydrocortisone + Efavirenz— CYP3A4 inducer may decrease serum hydrocortisone concentrations and increase risk of adrenal crisis; may require dose in…
- Hydrocortisone + Erythromycin— CYP3A4 inhibitor may increase serum hydrocortisone concentrations and risk of adverse reactions; may require dose decrea…
- Hydrocortisone + Estrogens— May increase serum cortisol-binding globulin, reducing hydrocortisone efficacy; may require dose increase.
- Hydrocortisone + Grapefruit Juice— CYP3A4 inhibitor may increase serum hydrocortisone concentrations and risk of adverse reactions; may require dose decrea…
- Hydrocortisone + Itraconazole— CYP3A4 inhibitor may increase serum hydrocortisone concentrations and risk of adverse reactions; may require dose decrea…
- Hydrocortisone + Ketoconazole— Inhibits metabolism of corticosteroids and decreases their clearance, requiring dose titration to avoid steroid toxicity…
- Hydrocortisone + Nevirapine— CYP3A4 inducer may decrease serum hydrocortisone concentrations and increase risk of adrenal crisis; may require dose in…
- Hydrocortisone + Oral Anticoagulants— Variable effect with reports of both enhanced and diminished anticoagulant effects when given concurrently with corticos…
- Hydrocortisone + Oxcarbazepine— CYP3A4 inducer may decrease serum hydrocortisone concentrations and increase risk of adrenal crisis; may require dose in…
- Hydrocortisone + Phenobarbital— Induces hepatic enzymes and increases clearance of corticosteroids, may require increased corticosteroid dose to achieve…
- Hydrocortisone + Phenytoin— Induces hepatic enzymes and increases clearance of corticosteroids, may require increased corticosteroid dose to achieve…
- Hydrocortisone + Posaconazole— CYP3A4 inhibitor may increase serum hydrocortisone concentrations and risk of adverse reactions; may require dose decrea…
- Hydrocortisone + Primidone— CYP3A4 inducer may decrease serum hydrocortisone concentrations and increase risk of adrenal crisis; may require dose in…
- Hydrocortisone + Rifabutin— CYP3A4 inducer may decrease serum hydrocortisone concentrations and increase risk of adrenal crisis; may require dose in…
- Hydrocortisone + Rifampin— Induces hepatic enzymes and increases clearance of corticosteroids, may require increased corticosteroid dose to achieve…
- Hydrocortisone + Ritonavir— CYP3A4 inhibitor may increase serum hydrocortisone concentrations and risk of adverse reactions; may require dose decrea…
- Hydrocortisone + Troleandomycin— Inhibits metabolism of corticosteroids and decreases their clearance, requiring dose titration to avoid steroid toxicity…
- Hydrocortisone + Voriconazole— CYP3A4 inhibitor may increase serum hydrocortisone concentrations and risk of adverse reactions; may require dose decrea…
- Hydrocortisone + Warfarin— Corticosteroids usually inhibit warfarin response; monitor coagulation indices to maintain anticoagulant effect.