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Prednisolone Sodium Phosphate

Also known as: Prednisolone Sodium Phosphate

Route: Oral

Check Prednisolone Sodium Phosphate Interactions →

26 interactions on record

Prednisolone Sodium Phosphate has 26 known drug interactions based on U.S. FDA drug labeling data. 15 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Aminoglutethimide, Amphotericin B, Anticholinesterase Agents. Patients taking Prednisolone Sodium Phosphate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 26
Major: 15
Moderate: 10

Major (15)

Prednisolone Sodium Phosphate + Aminoglutethimide— Aminoglutethimide may lead to loss of corticosteroid-induced adrenal suppression.
Prednisolone Sodium Phosphate + Amphotericin B— Concomitant use may result in cardiac enlargement and congestive heart failure, particularly due to potassium depletion.
Prednisolone Sodium Phosphate + Anticholinesterase Agents— Concurrent use may produce severe weakness in patients with myasthenia gravis; anticholinesterase agents should be withd…
Prednisolone Sodium Phosphate + Aspirin— Concomitant use increases risk of gastrointestinal side effects; use cautiously in hypoprothrombinemia.
Prednisolone Sodium Phosphate + Barbiturates— CYP 3A4 inducers enhance metabolism of prednisolone, requiring increased dosage of corticosteroid.
Prednisolone Sodium Phosphate + Carbamazepine— CYP 3A4 inducer enhances metabolism of prednisolone, requiring increased dosage of corticosteroid.
Prednisolone Sodium Phosphate + Cyclosporine— Concurrent use increases activity of both cyclosporin and corticosteroids with convulsions reported.
Prednisolone Sodium Phosphate + Digitalis Glycosides— Patients on digitalis glycosides may be at increased risk of arrhythmias due to hypokalemia from concurrent corticostero…
Prednisolone Sodium Phosphate + Ephedrine— CYP 3A4 inducer enhances metabolism of prednisolone, requiring increased dosage of corticosteroid.
Prednisolone Sodium Phosphate + Ketoconazole— Ketoconazole decreases metabolism of certain corticosteroids by up to 60%, leading to increased risk of corticosteroid s…
Prednisolone Sodium Phosphate + Live Attenuated Vaccines— Corticosteroids may potentiate replication of organisms in live attenuated vaccines and suppress antibody response; rout…
Prednisolone Sodium Phosphate + Macrolide Antibiotics— CYP 3A4 inhibitors that may decrease metabolism of corticosteroids, increasing risk of side effects.
Prednisolone Sodium Phosphate + Phenytoin— CYP 3A4 inducer enhances metabolism of prednisolone, requiring increased dosage of corticosteroid.
Prednisolone Sodium Phosphate + Rifampin— CYP 3A4 inducer enhances metabolism of prednisolone, requiring increased dosage of corticosteroid.
Prednisolone Sodium Phosphate + Salicylates— Concomitant use increases gastrointestinal side effects; clearance of salicylates may be increased.

Moderate (10)

Prednisolone Sodium Phosphate + Acidifying Agents— Corticosteroids may increase blood glucose concentrations, requiring dosage adjustments of antidiabetic agents.
Prednisolone Sodium Phosphate + Cholestyramine Light— Cholestyramine may increase the clearance of corticosteroids.
Prednisolone Sodium Phosphate + Diuretics— Potassium-depleting diuretics used with corticosteroids require close observation for hypokalemia development.
Prednisolone Sodium Phosphate + Estrogens— Estrogens decrease hepatic metabolism of certain corticosteroids, increasing their effect.
Prednisolone Sodium Phosphate + Inactivated Vaccines— Prolonged corticosteroid therapy may diminish response to inactivated vaccines due to inhibition of antibody response.
Prednisolone Sodium Phosphate + Isoniazid— Serum concentrations of isoniazid may be decreased by corticosteroid co-administration.
Prednisolone Sodium Phosphate + Oral Contraceptives— Oral contraceptives may decrease hepatic metabolism of corticosteroids, thereby increasing their effect.
Prednisolone Sodium Phosphate + Toxoids— Prolonged corticosteroid therapy may diminish response to toxoids due to inhibition of antibody response; routine admini…
Prednisolone Sodium Phosphate + Vaccines— Corticosteroids may diminish response to live or inactivated vaccines and potentiate replication of organisms in live at…
Prednisolone Sodium Phosphate + Warfarin— Corticosteroids usually inhibit response to warfarin; coagulation indices should be monitored frequently to maintain ant…

Prednisolone Sodium Phosphate + Aminoglutethimide⚠️Major

Aminoglutethimide may lead to loss of corticosteroid-induced adrenal suppression.

Prednisolone Sodium Phosphate + Amphotericin B⚠️Major

Concomitant use may result in cardiac enlargement and congestive heart failure, particularly due to potassium depletion.

Prednisolone Sodium Phosphate + Anticholinesterase Agents⚠️Major

Concurrent use may produce severe weakness in patients with myasthenia gravis; anticholinesterase agents should be withdrawn 24 hours before initiating corticosteroids if possible.

Prednisolone Sodium Phosphate + Aspirin⚠️Major

Concomitant use increases risk of gastrointestinal side effects; use cautiously in hypoprothrombinemia.

Prednisolone Sodium Phosphate + Barbiturates⚠️Major

CYP 3A4 inducers enhance metabolism of prednisolone, requiring increased dosage of corticosteroid.

Prednisolone Sodium Phosphate + Carbamazepine⚠️Major

CYP 3A4 inducer enhances metabolism of prednisolone, requiring increased dosage of corticosteroid.

Prednisolone Sodium Phosphate + Cyclosporine⚠️Major

Concurrent use increases activity of both cyclosporin and corticosteroids with convulsions reported.

Prednisolone Sodium Phosphate + Digitalis Glycosides⚠️Major

Patients on digitalis glycosides may be at increased risk of arrhythmias due to hypokalemia from concurrent corticosteroid use.

Prednisolone Sodium Phosphate + Ephedrine⚠️Major

CYP 3A4 inducer enhances metabolism of prednisolone, requiring increased dosage of corticosteroid.

Prednisolone Sodium Phosphate + Ketoconazole⚠️Major

Ketoconazole decreases metabolism of certain corticosteroids by up to 60%, leading to increased risk of corticosteroid side effects.

Prednisolone Sodium Phosphate + Live Attenuated Vaccines⚠️Major

Corticosteroids may potentiate replication of organisms in live attenuated vaccines and suppress antibody response; routine vaccination should be deferred until therapy discontinued.

Prednisolone Sodium Phosphate + Macrolide Antibiotics⚠️Major

CYP 3A4 inhibitors that may decrease metabolism of corticosteroids, increasing risk of side effects.

Prednisolone Sodium Phosphate + Phenytoin⚠️Major

CYP 3A4 inducer enhances metabolism of prednisolone, requiring increased dosage of corticosteroid.

Prednisolone Sodium Phosphate + Rifampin⚠️Major

CYP 3A4 inducer enhances metabolism of prednisolone, requiring increased dosage of corticosteroid.

Prednisolone Sodium Phosphate + Salicylates⚠️Major

Concomitant use increases gastrointestinal side effects; clearance of salicylates may be increased.

Prednisolone Sodium Phosphate + Acidifying Agents🟡Moderate

Corticosteroids may increase blood glucose concentrations, requiring dosage adjustments of antidiabetic agents.

Prednisolone Sodium Phosphate + Cholestyramine Light🟡Moderate

Cholestyramine may increase the clearance of corticosteroids.

Prednisolone Sodium Phosphate + Diuretics🟡Moderate

Potassium-depleting diuretics used with corticosteroids require close observation for hypokalemia development.

Prednisolone Sodium Phosphate + Estrogens🟡Moderate

Estrogens decrease hepatic metabolism of certain corticosteroids, increasing their effect.

Prednisolone Sodium Phosphate + Inactivated Vaccines🟡Moderate

Prolonged corticosteroid therapy may diminish response to inactivated vaccines due to inhibition of antibody response.

Prednisolone Sodium Phosphate + Isoniazid🟡Moderate

Serum concentrations of isoniazid may be decreased by corticosteroid co-administration.

Prednisolone Sodium Phosphate + Oral Contraceptives🟡Moderate

Oral contraceptives may decrease hepatic metabolism of corticosteroids, thereby increasing their effect.

Prednisolone Sodium Phosphate + Toxoids🟡Moderate

Prolonged corticosteroid therapy may diminish response to toxoids due to inhibition of antibody response; routine administration should be deferred if possible.

Prednisolone Sodium Phosphate + Vaccines🟡Moderate

Corticosteroids may diminish response to live or inactivated vaccines and potentiate replication of organisms in live attenuated vaccines.

Prednisolone Sodium Phosphate + Warfarin🟡Moderate

Corticosteroids usually inhibit response to warfarin; coagulation indices should be monitored frequently to maintain anticoagulant effect.

Prednisolone Sodium Phosphate + Prednisoloneℹ️Unknown

Drug Interactions Drugs such as barbiturates, phenytoin, ephedrine, and rifampin, which induce hepatic microsomal drug metabolizing enzyme activity may enhance metabolism of prednisolone and require that the dosage of Prednisolone Sodium Phosphate Oral Solution (15 mg Prednisolone per 5 mL) be increased.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.