Hydroxychloroquine has 13 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cimetidine, Mefloquine, Rifampin. Patients taking Hydroxychloroquine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 13
- Major
- 3
- Moderate
- 10
Major (3)
- Hydroxychloroquine + Cimetidine— Cimetidine causes 2-fold increase in chloroquine exposure; concomitant use should be avoided.
- Hydroxychloroquine + Mefloquine— Co-administration may increase the risk of seizures as both drugs lower seizure threshold.
- Hydroxychloroquine + Rifampin— Lack of efficacy of hydroxychloroquine reported; concomitant use should be avoided.
Moderate (10)
- Hydroxychloroquine + Ampicillin— Chloroquine significantly reduces ampicillin bioavailability; similar interaction with hydroxychloroquine cannot be rule…
- Hydroxychloroquine + Cyclosporine— Increased plasma cyclosporine levels reported; close monitoring of serum levels necessary.
- Hydroxychloroquine + Digoxin— May result in increased serum digoxin levels; close monitoring of serum levels necessary.
- Hydroxychloroquine + Heparin Sodium— Interferes with platelet aggregation and may induce bleeding. Use with caution; dose reduction of antiplatelet agent or …
- Hydroxychloroquine + Insulin Human— Hydroxychloroquine may enhance insulin effects and increase hypoglycemic risk; dosage adjustment may be necessary.
- Hydroxychloroquine + Methotrexate— Concomitant use may increase the incidence of adverse reactions.
- Hydroxychloroquine + Metoprolol— Potent CYP2D6 inhibitor may increase plasma concentration of metoprolol, decreasing cardioselectivity.
- Hydroxychloroquine + Metoprolol Tartrate— Potent CYP2D6 inhibitor may increase metoprolol plasma concentration, decreasing cardioselectivity.
- Hydroxychloroquine + Metoprolol Tartrate And Hydrochlorothiazide— Potent CYP2D6 inhibitor may increase plasma concentration of metoprolol; caution should be exercised.
- Hydroxychloroquine + Praziquantel— Chloroquine reduces praziquantel bioavailability; similar interaction with hydroxychloroquine cannot be ruled out.