Prolonged paralysis reported when succinylcholine given with anticholinesterase-active drugs; use with caution.
Source: NLP:pralidoxime chloride
Pralidoxime Chloride Interactions
Brand names: Protopam Chloride
Route: Intramuscular, Intravenous, Subcutaneous
Contraindications
CONTRAINDICATIONS There are no known absolute contraindications for the use of PROTOPAM Chloride (see PRECAUTIONS, Drug Interactions and DOSAGE AND ADMINISTRATION ). Relative contraindications include known hypersensitivity to the drug and other situations in which the risk of its use clearly outweighs possible benefit.
Pregnancy & Breastfeeding
Pregnancy Teratogenic Effects: Animal reproduction studies have not been conducted with pralidoxime chloride. It is also not known whether pralidoxime chloride can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Pralidoxime chloride should be given to a pregnant woman only if clearly needed.
2 interactions on record
Pralidoxime Chloride + AtropineModerate
Signs of atropinization (flushing, mydriasis, tachycardia, dryness of mouth/nose) may occur earlier than expected, especially with large atropine doses or delayed pralidoxime administration.
Source: NLP:pralidoxime chloride